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- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
Biological Activity
PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.
Targets
Procaspase-3 | ||||
0.22 μM(EC50) |
In vitro (25°C) | DMSO | 75 mg/mL (191.09 mM) | |
Water | Insoluble | ||
Ethanol | 15 mg/mL (38.21 mM) | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.48 mL | 127.39 mL | 254.78 mL |
0.5 mM | 5.1 mL | 25.48 mL | 50.96 mL |
1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
*The above data is based on the productmolecular weight 392.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11090 |
---|---|
Actions | Activator |
CAS No. | 315183-21-2 |
Formula | C23H28N4O2 |
M. Wt | 392.5 |
Purity | >98% |
Synonyms | PAC1,first procaspase activating compound |
SMILES | C=CCC1=CC=C/C(=C/NNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)/C1=O |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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