PAC-1

Catalog No.: A11090

Caspase activator

PAC-1

PAC-1 Chemical Structure

CAS NO. 315183-21-2

PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.

Availability: In stock

Package Price Qty
10 mg
$40.00
50 mg
$140.00
100 mg
$250.00
200 mg
$450.00
10mM * 1mL in DMSO
$50.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Biological Activity

PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.
Targets
Procaspase-3
0.22 μM(EC50)
In vitro (25°C) DMSO 75 mg/mL (191.09 mM)
Water Insoluble
Ethanol 15 mg/mL (38.21 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.48 mL 127.39 mL 254.78 mL
0.5 mM 5.1 mL 25.48 mL 50.96 mL
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL

*The above data is based on the productmolecular weight 392.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11090
Actions Activator
CAS No. 315183-21-2
Formula C23H28N4O2
M. Wt 392.5
Solubility DMSO
Purity >98%
Synonyms PAC1,first procaspase activating compound
SMILES C=CCC1=CC=C/C(=C/NNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)/C1=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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