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PD153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR.
Targets
| EGFR (Cell-free assay) | EGFR (Cell-free assay) | |||
| 5.2 pM(Ki) | 5.2 pM(Ki) |
| In vitro (25°C) | DMSO | 0.5 mg/mL (1.26 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% Propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.21 mL | 126.04 mL | 252.08 mL |
| 0.5 mM | 5.04 mL | 25.21 mL | 50.42 mL |
| 1 mM | 2.52 mL | 12.6 mL | 25.21 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.04 mL |
*The above data is based on the productmolecular weight 396.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10702 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 396.7 |
| Formula | C16H14BrN3O2.HCl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 183322-45-4 |
| Synonyms | ZM 252868, AG 1517, Tyrphostin AG 1517, SU 5271, PD-153035 |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl |
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