PD153035 (HCl salt)

Catalog No.: A10702

EGFR inhibitor

PD153035 (HCl salt)

PD153035 (HCl salt) Chemical Structure

CAS NO. 183322-45-4

PD153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR.

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Biological Activity

PD153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR.
EGFR (Cell-free assay) EGFR (Cell-free assay)
5.2 pM(Ki)5.2 pM(Ki)
In vitro (25°C) DMSO 0.46 mg/mL (1.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.21 mL 126.04 mL 252.08 mL
0.5 mM 5.04 mL 25.21 mL 50.42 mL
1 mM 2.52 mL 12.6 mL 25.21 mL
5 mM 0.5 mL 2.52 mL 5.04 mL

*The above data is based on the productmolecular weight 396.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10702
Actions Inhibitor
CAS No. 183322-45-4
Formula C16H14BrN3O2.HCl
M. Wt 396.7
Purity >98%
Synonyms ZM 252868, AG 1517, Tyrphostin AG 1517, SU 5271, PD-153035

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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