PD153035 (HCl salt)

Name: PD153035 (HCl salt)
Brand: Adooq Bioscience
SKU: A10702
Rating: 100 (268 reviews)

Catalog No.: A10702

EGFR inhibitor

PD153035 (HCl salt) Chemical Structure

CAS NO. 183322-45-4

PD153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR.

Availability: In stock

Package	Price	Qty
10 mg	$50.00
50 mg	$220.00
100 mg	$380.00
200 mg	$630.00
Custom Size	Get quote

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Biological Activity

PD153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR.

Targets

EGFR (Cell-free assay)	EGFR (Cell-free assay)
5.2 pM(Ki)	5.2 pM(Ki)

Solubility *

In vitro (25°C)	DMSO	0.46 mg/mL (1.16 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.21 mL	126.04 mL	252.08 mL
0.5 mM	5.04 mL	25.21 mL	50.42 mL
1 mM	2.52 mL	12.6 mL	25.21 mL
5 mM	0.5 mL	2.52 mL	5.04 mL

*The above data is based on the productmolecular weight 396.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10702
Actions	Inhibitor
CAS No.	183322-45-4
Formula	C16H14BrN3O2.HCl
M. Wt	396.7
Solubility	DMSO
Purity	>98%
Synonyms	ZM 252868, AG 1517, Tyrphostin AG 1517, SU 5271, PD-153035
SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.