Pelitinib (EKB-569)

Catalog No.: A10706

EGFR inhibitor

Pelitinib (EKB-569)

Pelitinib (EKB-569) Chemical Structure

CAS NO. 257933-82-7

Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$45.00
10 mg
$65.00
25 mg
$110.00
100 mg
$200.00
10mM * 1mL in DMSO
$120.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Shi P, .et al. The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR Mutations, Transl Oncol, 2019, Mar 8;12(5):705-713 PMID: 30856555

Biological Activity

Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
Targets
Target Value
EGFRIC50: 38.5nM
SrcIC50: 282nM
MEK/ERKIC50: 800nM
ErbB2IC50: 1.255μM
RafIC50: 3.353μM
c-MetIC50: 4.1μM
CDK4IC50: >20μM
In vitro DMSO 12 mg/mL (25.64 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.37 mL 106.86 mL 213.72 mL
0.5 mM 4.27 mL 21.37 mL 42.74 mL
1 mM 2.14 mL 10.69 mL 21.37 mL
5 mM 0.43 mL 2.14 mL 4.27 mL

*The above data is based on the productmolecular weight 467.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10706
Actions Inhibitor
CAS No. 257933-82-7
Formula C24H23ClFN5O2
M. Wt 467.9
Purity >98%
Synonyms WAY-EKB 569
SMILES CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)/C=C/CN(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy Pelitinib (EKB-569) | Pelitinib (EKB-569) Supplier | purchase | cost | manufacturer | order | distributor | buy 257933-82-7| 257933-82-7 Supplier | purchase 257933-82-7 | 257933-82-7 cost | 257933-82-7 manufacturer | order 257933-82-7 | 257933-82-7 distributor
Rewards