Pelitinib (EKB-569)

Catalog No.: A10706

EGFR inhibitor

Pelitinib (EKB-569)

Pelitinib (EKB-569) Chemical Structure

CAS NO. 257933-82-7

Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.

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5 mg
10 mg
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100 mg
10mM * 1mL in DMSO
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  • Shi P, .et al. The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR Mutations, Transl Oncol, 2019, Mar 8;12(5):705-713 PMID: 30856555

Biological Activity

Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
Target Value
EGFRIC50: 38.5nM
SrcIC50: 282nM
MEK/ERKIC50: 800nM
ErbB2IC50: 1.255μM
RafIC50: 3.353μM
c-MetIC50: 4.1μM
CDK4IC50: >20μM
In vitro DMSO 12 mg/mL (25.64 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.37 mL 106.86 mL 213.72 mL
0.5 mM 4.27 mL 21.37 mL 42.74 mL
1 mM 2.14 mL 10.69 mL 21.37 mL
5 mM 0.43 mL 2.14 mL 4.27 mL

*The above data is based on the productmolecular weight 467.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10706
Actions Inhibitor
CAS No. 257933-82-7
Formula C24H23ClFN5O2
M. Wt 467.9
Purity >98%
Synonyms WAY-EKB 569

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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