Pelitinib (EKB-569)

Name: Pelitinib (EKB-569)
Brand: Adooq Bioscience
SKU: A10706
Rating: 100 (1 reviews)

Catalog No.: A10706

EGFR inhibitor

Product Citations (1)

Pelitinib (EKB-569) Chemical Structure

CAS NO. 257933-82-7

Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.

Availability: In stock

Package	Price	Qty
5 mg	$45.00
10 mg	$65.00
25 mg	$110.00
100 mg	$200.00
10mM * 1mL in DMSO	$120.00
Custom Size	Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Bulk Inquiry

Get Free Sample

Price Match

Add to Wishlist

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Pelitinib (EKB-569)

Shi P, .et al. The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR Mutations, Transl Oncol, 2019, Mar 8;12(5):705-713 PMID: 30856555

Biological Activity

Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.

Targets

Target	Value
EGFR	IC50: 38.5nM
Src	IC50: 282nM
MEK/ERK	IC50: 800nM
ErbB2	IC50: 1.255μM
Raf	IC50: 3.353μM
c-Met	IC50: 4.1μM
CDK4	IC50: >20μM

Solubility *

In vitro	DMSO	12 mg/mL (25.64 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.37 mL	106.86 mL	213.72 mL
0.5 mM	4.27 mL	21.37 mL	42.74 mL
1 mM	2.14 mL	10.69 mL	21.37 mL
5 mM	0.43 mL	2.14 mL	4.27 mL

*The above data is based on the productmolecular weight 467.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10706
Actions	Inhibitor
CAS No.	257933-82-7
Formula	C24H23ClFN5O2
M. Wt	467.9
Purity	>98%
Synonyms	WAY-EKB 569
SMILES	CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)/C=C/CN(C)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.