Pelitinib (EKB-569)

Catalog No.: A10706

EGFR inhibitor

Pelitinib (EKB-569)

Pelitinib (EKB-569) Chemical Structure

CAS NO. 257933-82-7

Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$45.00
10 mg
$65.00
25 mg
$110.00
100 mg
$200.00
10mM * 1mL in DMSO
$120.00
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Biological Activity

Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
Targets
Target Value
EGFRIC50: 38.5nM
SrcIC50: 282nM
MEK/ERKIC50: 800nM
ErbB2IC50: 1.255μM
RafIC50: 3.353μM
c-MetIC50: 4.1μM
CDK4IC50: >20μM
In vitro (25°C) DMSO 13 mg/mL (27.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.37 mL 106.86 mL 213.72 mL
0.5 mM 4.27 mL 21.37 mL 42.74 mL
1 mM 2.14 mL 10.69 mL 21.37 mL
5 mM 0.43 mL 2.14 mL 4.27 mL

*The above data is based on the productmolecular weight 467.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10706
Actions Inhibitor
M. Wt 467.9
Formula C24H23ClFN5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 257933-82-7
Synonyms WAY-EKB 569
SMILES CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)/C=C/CN(C)C

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