Perampanel

Catalog No.: A12498

GluR antagonist

Perampanel

Perampanel Chemical Structure

CAS NO. 380917-97-5

Perampanel is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
25 mg
$260.00
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  • Citlalli Netzahualcoyotzi, .et al. Neuronal and astroglial monocarboxylate transporters play key but distinct roles in hippocampus-dependent learning and memory formation, Prog Neurobiol, 2020, Jul 18;101888 PMID: 32693190
  • Bostwick M, .et al. Antagonistic Inhibitory Circuits Integrate Visual and Gravitactic Behaviors, Curr Biol, 2020, Feb 24;30(4):600-609 PMID: 32008899
  • HS Venkatesh, .et al. Electrical and synaptic integration of glioma into neural circuits, Nature, 2019, 573:539-545 PMID: 31534222
  • Nozawa A, .et al. Perampanel Inhibits Neuroblastoma Cell Proliferation Through Down-regulation of AKT and ERK Pathways, Anticancer Res, 2019, 39(7): 3595-3599 PMID: 31262884
  • Matthew Kourakis, .et al. Parallel Visual Circuitry in a Basal Chordate, bioRxiv, 2019, Jan. 8 2019

Biological Activity

Perampanel is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials.
Targets
AMPA glutamate receptor
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.62 mL 143.11 mL 286.22 mL
0.5 mM 5.72 mL 28.62 mL 57.24 mL
1 mM 2.86 mL 14.31 mL 28.62 mL
5 mM 0.57 mL 2.86 mL 5.72 mL

*The above data is based on the productmolecular weight 349.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12498
Actions Antagonist
M. Wt 349.38
Formula C23H15N3O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 380917-97-5
SMILES C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4

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