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PF-04457845 is a potent and exquisitely selective inhibitor of FAAH, with an IC50 of 7.2 nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.96 mL | 109.79 mL | 219.57 mL |
| 0.5 mM | 4.39 mL | 21.96 mL | 43.91 mL |
| 1 mM | 2.2 mL | 10.98 mL | 21.96 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.39 mL |
*The above data is based on the productmolecular weight 455.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15209 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 455.43 |
| Formula | C23H20F3N5O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1020315-31-4 |
| Synonyms | PF 04457845, PF04457845 |
| SMILES | C1CN(CCC1=CC2=CC(=CC=C2)OC3=NC=C(C=C3)C(F)(F)F)C(=O)NC4=NN=CC=C4 |
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