PF 4708671

Catalog No.: A11755
S6 kinase inhibitor
PF 4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) that inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 , while having no effect on highly related RSK and MSK kinases.
Grouped product items
Product Name Price Stock Qty
PF 4708671 10mg
Special Price $48.00 Regular Price $60.00
In stock
PF 4708671 25mg
Special Price $96.00 Regular Price $120.00
In stock
PF 4708671 50mg
Special Price $160.00 Regular Price $200.00
In stock
PF 4708671 100mg
Special Price $280.00 Regular Price $350.00
In stock
PF 4708671 10mM * 1mL in DMSO
Special Price $65.60 Regular Price $82.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's PF 4708671 has been cited by 2 publications
  • Amnon Wittenstein, .et al. , PLoS Biol, 2023, Nov 9;21(11):e3002355 PMID: 37943958
  • Nogami A, .et al. , Transl Oncol, 2018, Nov 22;12(2):336-349 PMID: 30472492
  • Biological Activity
    Discription PF 4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) that inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 , while having no effect on highly related RSK and MSK kinases.
    Targets
    Target Value
    Product Information
    Catalog Num A11755
    Formula C19H21F3N6
    Molecular Weight 390.4
    CAS Number 1255517-76-0
    SMILES CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F
    Synonyms PF4708671, PF-4708671
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 30 mg/mL (76.84 mM)
    Water Insoluble
    Ethanol 8 mg/mL (20.49 mM)
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 25.61 mL 128.07 mL 256.15 mL
    0.5 mM 5.12 mL 25.61 mL 51.23 mL
    1 mM 2.56 mL 12.81 mL 25.61 mL
    5 mM 0.51 mL 2.56 mL 5.12 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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