PF 4708671

Catalog No.: A11755

S6 kinase inhibitor

PF 4708671

PF 4708671 Chemical Structure

CAS NO. 1255517-76-0

PF 4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) that inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 , while having no effect on highly related RSK and MSK kinases.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $60.00

Special Price $54.00

25 mg

Regular Price: $120.00

Special Price $108.00

50 mg

Regular Price: $200.00

Special Price $180.00

100 mg

Regular Price: $350.00

Special Price $315.00

10mM * 1mL in DMSO

Regular Price: $82.00

Special Price $73.80

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF 4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) that inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 , while having no effect on highly related RSK and MSK kinases.
Targets
p70 S6K1 (Cell-free assay)
160 nM
In vitro (25°C) DMSO 30 mg/mL (76.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol 8 mg/mL (20.49 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.61 mL 128.07 mL 256.15 mL
0.5 mM 5.12 mL 25.61 mL 51.23 mL
1 mM 2.56 mL 12.81 mL 25.61 mL
5 mM 0.51 mL 2.56 mL 5.12 mL

*The above data is based on the productmolecular weight 390.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11755
Actions Inhibitor
M. Wt 390.4
Formula C19H21F3N6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1255517-76-0
Synonyms PF4708671, PF-4708671
SMILES CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F

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