PF 573228

Catalog No.: A11235

FAK Inhibitor

PF 573228

PF 573228 Chemical Structure

CAS NO. 869288-64-2

PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM).

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10 mg
25 mg
50 mg
100 mg
10mM * 1mL in DMSO
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  • Izumi D, .et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer, Int J Cancer, 2016, Mar 1;138(5):1207-19 PMID: 26414794
  • Aya Yokota-Nakatsuma, .et al. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties, Sci Rep, 2016, 6: 37914 PMID: 27897208

Biological Activity

PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM).
FAK (Cell-free assay)
4 nM
In vitro (25°C) DMSO 24 mg/mL (48.83 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+2% Tween 80+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.35 mL 101.73 mL 203.46 mL
0.5 mM 4.07 mL 20.35 mL 40.69 mL
1 mM 2.03 mL 10.17 mL 20.35 mL
5 mM 0.41 mL 2.03 mL 4.07 mL

*The above data is based on the productmolecular weight 491.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11235
Actions Inhibitor
CAS No. 869288-64-2
Formula C22H20F3N5O3S
M. Wt 491.5
Solubility DMSO
Purity >98%
Synonyms PF-573228, PF573228

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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