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Catalog No.: A10713

c-Met Inhibitor


PHA-665752 Chemical Structure

CAS NO. 477575-56-7

PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Biological Activity

PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling.
Target Value
c-MetIC50: 9nM
RONIC50: 68nM
Flk1IC50: 200nM
c-AblIC50: 1.4μM
FGFR1IC50: 3μM
EGFRIC50: 3.8μM
c-SrcIC50: 6μM
IGF-1RIC50: >10μM
PDGFRIC50: >10μM
AuroraA2IC50: >10μM
PKAIC50: >10μM
PKBαIC50: >10μM
CDK2IC50: >10μM
p38αIC50: >10μM
MK2IC50: >10μM
MK3IC50: >10μM
In vitro (25°C) DMSO 124 mg/mL (193.26 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+castor oil 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.59 mL 77.93 mL 155.86 mL
0.5 mM 3.12 mL 15.59 mL 31.17 mL
1 mM 1.56 mL 7.79 mL 15.59 mL
5 mM 0.31 mL 1.56 mL 3.12 mL

*The above data is based on the productmolecular weight 641.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10713
Actions Inhibitor
CAS No. 477575-56-7
Formula C32H34Cl2N4O4S
M. Wt 641.6
Purity >98%
Synonyms PHA665752
SMILES CC1=C(NC(=C1C(=O)N2CCC[C@@H]2CN3CCCC3)C)/C=C\4/C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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