PHA-665752

Catalog No.: A10713

c-Met Inhibitor

PHA-665752

PHA-665752 Chemical Structure

CAS NO. 477575-56-7

PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $50.00

Special Price $45.00

10 mg

Regular Price: $80.00

Special Price $72.00

50 mg

Regular Price: $300.00

Special Price $270.00

100 mg

Regular Price: $560.00

Special Price $504.00

10mM * 1mL in DMSO

Regular Price: $90.00

Special Price $81.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling.
Targets
Target Value
c-MetIC50: 9nM
RONIC50: 68nM
Flk1IC50: 200nM
c-AblIC50: 1.4μM
FGFR1IC50: 3μM
EGFRIC50: 3.8μM
c-SrcIC50: 6μM
IGF-1RIC50: >10μM
PDGFRIC50: >10μM
AuroraA2IC50: >10μM
PKAIC50: >10μM
PKBαIC50: >10μM
CDK2IC50: >10μM
p38αIC50: >10μM
MK2IC50: >10μM
MK3IC50: >10μM
In vitro (25°C) DMSO 128 mg/mL (199.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.59 mL 77.93 mL 155.86 mL
0.5 mM 3.12 mL 15.59 mL 31.17 mL
1 mM 1.56 mL 7.79 mL 15.59 mL
5 mM 0.31 mL 1.56 mL 3.12 mL

*The above data is based on the productmolecular weight 641.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10713
Actions Inhibitor
M. Wt 641.6
Formula C32H34Cl2N4O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 477575-56-7
Synonyms PHA665752
SMILES CC1=C(NC(=C1C(=O)N2CCC[[email protected]@H]2CN3CCCC3)C)/C=C\4/C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O

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