PI3K

Catalog No.Inhibitor Name PI3K p110α p110β p110δ p110γC2α C2β Vps34 Other Targets
A10133Dactolisib (BEZ235, NVP-BEZ235)
****
**
***
***
mTOR (p70S6K),ATR
A10421Pictilisib (GDC-0941)
****
**
****
**
*
mTOR
A10547LY294002
*
*
*
A10172Idelalisib (CAL-101, GS-1101)
*
*
****
**
*
DNA-PK
A11016Buparlisib (BKM120, NVP-BKM120)
**
*
**
*
*
mTOR
A10726PI-103
****
****
****
***
DNA-PK,mTOR
A10923TGX-221
*
****
**
A10463IC-87114
*
**
*
A11161Wortmannin
****
DNA-PK,ATM,MLCK
A10995XL147 analogue
***
**
***
***
A11014ZSTK474
***
***
***
****
**
A11328Alpelisib (BYL719)
****
A10088AS-605240
**
*
*
***
A10729PIK-75 HCl
***
*
**
DNA-PK
A111513-Methyladenine (3-MA)
*
*
A11202A66
***
*
*
PI4Kβ
A10731PIK-93
***
*
**
***
*
**
*
PI4KIIIβ,DNA-PK,ATM
A11035Omipalisib (GSK2126458, GSK458)
****
****
****
****
mTORC1,mTORC2
A10730PIK-90
***
*
**
***
A11024PF-04691502
****
****
****
****
P-Akt (S473),P-Akt (T308),mTOR
A10112AZD6482
*
***
**
*
DNA-PK
A11023Apitolisib (GDC-0980, RG7422)
****
***
***
***
mTOR
A10438GSK1059615
****
****
****
****
mTOR
A12422Duvelisib (IPI-145, INK1197)
***
****
****
****
A11079Gedatolisib (PF-05212384, PKI-587)
****
****
mTOR
A10922TG100-115
*
*
**
**
A11099AS-252424
*
***
Casein Kinase 2
A11162BGT226 (NVP-BGT226)
****
**
***
mTOR
A11153CUDC-907
***
**
***
*
HDAC1,HDAC3,HDAC10
A10728PIK-294
*
***
**
A11197AS-604850
*
**
A11766Copanlisib (BAY 80-6946)
****
****
****
***
A11064YM201636
*
PIKfyve
A11169CH5132799
***
**
*
***
A10727PIK-293
*
*
**
*
A11089PKI-402
****
***
***
***
mTOR
A11956TG100713
**
**
***
**
A12480VS-5584 (SB2343)
****
***
****
****
mTOR
A12831Taselisib (GDC 0032)
****
***
****
****
*
*
A11363CZC24832
*
*
***
A16332IPI-549
*
*
*
***
A16277TGR-1202
***
A16272GDC-0084
****
**
****
***
mTOR
A16352AZD8835
***
*
****
**
A15868PIK-III
*
*
*
***
A15874VPS34-IN1
***
A16276Voxtalisib (XL765, SAR245409)
***
**
**
***
DNA-PK,mTOR
A15901AMG319
*
*
***
*
A15759AZD8186
***
****
***
*
A12889PF-4989216
****
**
****
**
A15283Pilaralisib (XL147)
**
***
***
***
A14338PI-3065
*
*
***
*
A13021HS-173
****
A10766Quercetin
*
*
*
PKC,Src,Sirtuin
A11784GSK2636771
A11196CAY10505
A16126LY3023414
DNA-PK,mTOR kinase
A13992GNE-317
A14441Acalisib (GS-9820)
A16273NVP-QAV-572
A16266ON 146040
***
***
A15992PQR309
A15529MLN1117 (Serabelisib)
***
A15030CAL-130
A14379Panulisib (P7170, AK151761)
ALK1, mTOR, DNA-PK
A13879 CNX-1351
****
A11198D-106669
****
A11261PX-866 (Sonolisib)
****
*
****
***
A11511NVP-BAG956
***
*
***
**
PDK1
A12935PF-04979064
****
****
****
****
mTOR
A13328ETP-46464
*
mTOR, DNA-PK, ATR, ATM
A14432GNE-493
****
***
***
***
mTOR

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. LY294002

    Catalog No. A10547
    Quick View
    PI3K Inhibitor
    LY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor. Learn More
  2. PIK-75

    Catalog No. A10729
    Quick View
    PI3K Inhibitor
    PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively. Learn More

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