Biological Activity
PIK-294 is a PI3 Kinase inhibitor that is 20- to 60-fold more potent than the parent compound, PIK-293. It is one of the most potent p110δ-selective inhibitors that has been reported.
Targets
p110δ | p110γ | p110β | ||
10 nM | 160 nM | 490 nM |
In vitro | DMSO | 91 mg/mL (185.89 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.43 mL | 102.15 mL | 204.29 mL |
0.5 mM | 4.09 mL | 20.43 mL | 40.86 mL |
1 mM | 2.04 mL | 10.21 mL | 20.43 mL |
5 mM | 0.41 mL | 2.04 mL | 4.09 mL |
*The above data is based on the productmolecular weight 489.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10728 |
---|---|
Actions | Inhibitor |
CAS No. | 900185-02-6 |
Formula | C28H23N7O2 |
M. Wt | 489.5 |
Purity | >98% |
Synonyms | PIK294 |
SMILES | CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C5=C(C(=N4)C6=CC(=CC=C6)O)C(=NC=N5)N |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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