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| Catalog No. | Inhibitor Name | PARP | PARP1 | PARP2 | PARP3 | V-PARP | Tankyrase-1 |
|---|---|---|---|---|---|---|---|
| A10111 | Olaparib | *** | **** | * | |||
| A10026 | Veliparib | *** | *** | ||||
| A14182 | Rucaparib | **** | |||||
| A11243 | Talazoparib | **** | |||||
| A10046 | AG-14361 | *** | |||||
| A10475 | INO-1001 | ** | |||||
| A10019 | A-966492 | **** | **** | ||||
| A15215 | PJ34 | *** | |||||
| A12665 | PJ34 HCl | *** | |||||
| A11026 | Niraparib | *** | **** | * | ** | ** | |
| A12750 | UPF 1069 | * | ** | ||||
| A14309 | ME0328 | * | ** | ||||
| A14371 | Benzamide | * | |||||
| A15375 | NU1025 | ** | |||||
| A10164 | Iniparib | ||||||
| A12393 | AZD2461 | ||||||
| A16344 | BGP-15 | ||||||
| A10045 | AG-014699 (Rucaparib) | **** | |||||
| A15370 | 4-HQN | * | |||||
| A15371 | BYK 204165 | * | * | ||||
| A15372 | BYK 49187 | * | * | ||||
| A15374 | EB 47 | ** | |||||
| A15373 | DR 2313 | * | ** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
49 Item(s)
per page
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EB 47
Catalog No. A15374 -
INO-1001
Catalog No. A20680 PARP inhibitorINO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. Learn More -
PARP-2-IN-1
Catalog No. A20240 PARP-2 inhibitorPARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC50 of 11.5 nM. Learn More -
Talazoparib tosylate
Catalog No. A20238 PARP1/2 inhibitorTalazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC50 of 0.57 nM for PARP1. Learn More -
GeA-69
Catalog No. A19705 PARP14 inhibitorGeA-69 is a selective, highly cell permeable allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2, with a Kd of 2.1 ?M. Learn More -
AZ6102
Catalog No. A15873 TNKS1/2 inhibitorAZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells. Learn More -
MN-64
Catalog No. A15927 TNKS inhibitorMN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). Learn More -
NVP-TNKS656
Catalog No. A15786 TNKS2 inhibitorNVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2. Learn More -
G007-LK
Catalog No. A15528 TNKS inhibitorG007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice, Learn More -
NU 1025
Catalog No. A15375 PARP inhibitorNU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. Learn More -
DR 2313
Catalog No. A15373 PARP inhibitorPARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor. Learn More -
BYK 49187
Catalog No. A15372 PARP-1/PARP-2 inhibitorBYK 49187, PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Learn More -
BYK 204165
Catalog No. A15371 PARP-1 inhibitorBYK204165 is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1). Learn More -
4-HQN
Catalog No. A15370 PARP inhibitor4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. Learn More -
JW 55
Catalog No. A13731 TNKS1/2 inhibitorJW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Learn More -
E7449
Catalog No. A21553 PARP1/PARP2 inhibitorE7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. Learn More -
Lanifibranor
Catalog No. A17041 PARP agonistLanifibranor, also known as IVA-337, is a peroxisome proliferator-activated receptors (PPAR) agonist. Learn More -
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New
XMD8-87
Catalog No. A17134 TNK2 InhibitorXMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 μM Learn More -
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New
XMD16-5
Catalog No. A17130 -
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Rucaparib (Camsylate)
Catalog No. A18013 PARP inhibitorRucaparib Camsylate is an inhibitor of PARP with a Ki of 1.4 nM for PARP1, and also shows binding affinity to eight other PARP domains. Learn More -
NMS-P515
Catalog No. A18449 PARP-1 inhibitorNMS-P515 is a potent inhibitor of PARP-1 both in biochemical (Kd: 0.016 μM) and cellular (IC50: 0.027 μM) assays. Learn More -
PARP14 inhibitor H10
Catalog No. A18616 PARP14 inhibitorPARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (??24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis. Learn More -
Niraparib tosylate
Catalog No. A16618 PARP1/PARP2 inhibitorNiraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. Learn More -
Niraparib hydrochloride
Catalog No. A18018 PARP1 and PARP2 inhibitorNiraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Learn More -
BGP-15
Catalog No. A16344 PARP inhibitorBGP-15 is a PARP inhibitor, that can protect against heart failure and atrial fibrillation in mice. Learn More -
Niraparib R-enantiomer
Catalog No. A21880 PARP1 inhibitorNiraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM. Learn More -
Veliparib dihydrochloride
Catalog No. A21356 PARP inhibitorVeliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. Learn More -
NMS-P118
Catalog No. A20994 PARP-1 InhibitorNMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy. Learn More -
AG14361
Catalog No. A10046 PARP inhibitorAG14361 is a potent PARP inhibitor, enhanced TMZ cytotoxicity in MMR(mismatch repair)-proficient / deficient cells. Learn More -
AG-014699 (Rucaparib)
Catalog No. A10045 PARP inhibitorAG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair. Learn More -
BSI-201 (Iniparib)
Catalog No. A10164 PARP inhibitorBSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier. Learn More -
Olaparib (AZD2281)
Catalog No. A10111 PARP inhibitorOlaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. Learn More -
ABT-888 (Veliparib)
Catalog No. A10026 PARP inhibitorABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor. Learn More -
ME0328
Catalog No. A14309 PARP3 inhibitorME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. Learn More -
Benzamide
Catalog No. A14371 PARP-1 inhibitorBenzamide is the amide derivative of benzoic acid and an inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Learn More -
AIM-100
Catalog No. A14986 Ack1 (TNK2) inhibitorAIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM. Learn More -
BMN-673 8R,9S
Catalog No. A15024 PARP InhibitorBMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM. Learn More -
PJ34
Catalog No. A15215 PARP inhibitorPJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM. Learn More -
Rucaparib
Catalog No. A14182 PARP-1 inhibitorRucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells. Learn More -
AZD-2461
Catalog No. A12393 PARP InhibitorAZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein. Learn More -
UPF 1069
Catalog No. A12750 PARP2 inhibitorUPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively). Learn More -
Pamiparib
Catalog No. A17073 PARP inhibitorPamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. CAS: 1446261-44-1 (free base) 2086689-94-1 (maleate) 2086689-93-0 (hydrate) Learn More -
PJ 34 hydrochloride
Catalog No. A12665 PARP inhibitorPJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). Learn More -
BMN673
Catalog No. A11243 PARP inhibitorBMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Learn More -
MK-4827 (Niraparib)
Catalog No. A11026 PARP inhibitorMK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor. Learn More -
A-966492
Catalog No. A10019 PARP1 inhibitorA-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. Learn More -
3-Aminobenzamide
Catalog No. A10475 PARP Inhibitor3-Aminobenzamide is a novel PARP inhibitor, known to sensitize cells to radiation in vitro by inhibiting the repair of DNA damage. Learn More -
TC-E 5001
Catalog No. A11454 TNKS inhibitorTC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels. Learn More -
WIKI4
Catalog No. A14283 Tankyrase inhibitorWIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2. Learn More
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