PARP

Catalog No.Inhibitor Name PARPPARP1PARP2PARP3V-PARPTankyrase-1
A10111Olaparib
***
****
*
A10026Veliparib
***
***
A14182Rucaparib
****
A11243Talazoparib
****
A10046AG-14361
***
A10475INO-1001
**
A10019A-966492
****
****
A15215PJ34
***
A12665PJ34 HCl
***
A11026Niraparib
***
****
*
**
**
A12750UPF 1069
*
**
A14309ME0328
*
**
A14371Benzamide
*
A15375NU1025
**
A10164Iniparib
A12393AZD2461
A16344BGP-15
A10045AG-014699 (Rucaparib)
****
A153704-HQN
*
A15371BYK 204165
*
*
A15372BYK 49187
*
*
A15374EB 47
**
A15373DR 2313
*
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

36 Item(s)

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  1. G007-LK

    Catalog No. A15528
    TNKS inhibitor
    G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice, Learn More
  2. EB 47

    Catalog No. A15374
    PARP1 Inhibitor
    EB 47 is a potent inhibitor of PARP1 with IC50 of 45 nM. Learn More
  3. NVP-TNKS656

    Catalog No. A15786
    TNKS2 inhibitor
    NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2. Learn More
  4. MN-64

    Catalog No. A15927
    TNKS inhibitor
    MN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). Learn More
  5. AZ6102

    Catalog No. A15873
    TNKS1/2 inhibitor
    AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells. Learn More
  6. JW 55

    Catalog No. A13731
    TNKS1/2 inhibitor
    JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Learn More
  7. DR 2313

    Catalog No. A15373
    PARP inhibitor
    PARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor. Learn More
  8. BYK 49187

    Catalog No. A15372
    PARP-1/PARP-2 inhibitor
    BYK 49187, PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Learn More
  9. BYK 204165

    Catalog No. A15371
    PARP-1 inhibitor
    BYK204165 is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1). Learn More
  10. 4-HQN

    Catalog No. A15370
    PARP inhibitor
    4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. Learn More
  11. NU 1025

    Catalog No. A15375
    PARP inhibitor
    NU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. Learn More
  12. ABT-888 (Veliparib)

    Catalog No. A10026
    PARP inhibitor
    ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor. Learn More
  13. TC-E 5001

    Catalog No. A11454
    TNKS inhibitor
    TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels. Learn More
  14. BGP-15

    Catalog No. A16344
    PARP inhibitor
    BGP-15 is a PARP inhibitor, that can protect against heart failure and atrial fibrillation in mice. Learn More
  15. Pamiparib

    Catalog No. A17073
    PARP inhibitor
    Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. CAS: 1446261-44-1 (free base) 2086689-94-1 (maleate) 2086689-93-0 (hydrate) Learn More
  16. Lanifibranor

    Catalog No. A17041
    PARP agonist
    Lanifibranor, also known as IVA-337, is a peroxisome proliferator-activated receptors (PPAR) agonist. Learn More
    • New

    XMD8-87

    Catalog No. A17134
    TNK2 Inhibitor
    XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 μM Learn More
  17. PJ34

    Catalog No. A15215
    PARP inhibitor
    PJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM. Learn More
  18. BMN-673 8R,9S

    Catalog No. A15024
    PARP Inhibitor
    BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM. Learn More
  19. AIM-100

    Catalog No. A14986
    Ack1 (TNK2) inhibitor
    AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM. Learn More
  20. Olaparib (AZD2281)

    Catalog No. A10111
    PARP inhibitor
    Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. Learn More
  21. BSI-201 (Iniparib)

    Catalog No. A10164
    PARP inhibitor
    BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier. Learn More
  22. AG-014699 (Rucaparib)

    Catalog No. A10045
    PARP inhibitor
    AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair. Learn More
  23. AG14361

    Catalog No. A10046
    PARP inhibitor
    AG14361 is a potent PARP inhibitor, enhanced Temozolomide (TMZ) cytotoxicity in MMR(mismatch repair)-proficient / deficient cells. Learn More
  24. INO-1001

    Catalog No. A10475
    PARP Inhibitor
    INO-1001 is a novel PARP inhibitor, known to sensitize cells to radiation in vitro by inhibiting the repair of DNA damage. Learn More
  25. A-966492

    Catalog No. A10019
    PARP1 inhibitor
    A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. Learn More
  26. MK-4827 (Niraparib)

    Catalog No. A11026
    PARP inhibitor
    MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor. Learn More
  27. BMN673

    Catalog No. A11243
    PARP inhibitor
    BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Learn More
  28. PJ 34 hydrochloride

    Catalog No. A12665
    PARP inhibitor
    PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). Learn More
  29. UPF 1069

    Catalog No. A12750
    PARP2 inhibitor
    UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively). Learn More
  30. AZD-2461

    Catalog No. A12393
    PARP Inhibitor
    AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein. Learn More
  31. Rucaparib

    Catalog No. A14182
    PARP-1 inhibitor
    Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells. Learn More
  32. WIKI4

    Catalog No. A14283
    Tankyrase inhibitor
    WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2. Learn More
  33. ME0328

    Catalog No. A14309
    PARP3 inhibitor
    ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. Learn More
  34. Benzamide

    Catalog No. A14371
    PARP-1 inhibitor
    Benzamide is the amide derivative of benzoic acid and an inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Learn More
    • New

    XMD16-5

    Catalog No. A17130
    TNK2 inhibitor
    XMD16-5 is a tyrosine kinase nonreceptor 2(TNK2) inhibitor. Learn More

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