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Catalog No.: A13190

DUB inhibitor


PR-619 Chemical Structure

CAS NO. 2645-32-1

PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).

Availability: In stock

Package Price Qty
5 mg
10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Anurag Rathore, .et al. CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models, Sci Rep, 2020, 10: 5350 PMID: 32210344

Biological Activity

PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).
Target Value
JOSD2EC50: 1.17μM
SENP6coreEC50: 2.37μM
UCH-L3EC50: 2.95μM
USP4EC50: 3.93μM
USP8EC50: 4.90μM
DEN1EC50: 4.98μM
USP20EC50: 5.10μM
USP28EC50: 6.24μM
USP7EC50: 6.86μM
USP2coreEC50: 7.20μM
USP15EC50: 8.23μM
USP5EC50: 8.61μM
USP47EC50: 8.87μM
UCH-L5EC50: 9.26μM
UCH-L1EC50: 12.8μM
PlproEC50: 14.2μM
PLA2EC50: >50μM
Calpain1EC50: >50μM
CT-LEC50: >50μM
CathepsinDEC50: >50μM
MMP13EC50: >50μM
TrypsinEC50: >50μM
In vitro DMSO 42 mg/mL (188.1 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 44.79 mL 223.93 mL 447.87 mL
0.5 mM 8.96 mL 44.79 mL 89.57 mL
1 mM 4.48 mL 22.39 mL 44.79 mL
5 mM 0.9 mL 4.48 mL 8.96 mL

*The above data is based on the productmolecular weight 223.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13190
Actions Inhibitor
CAS No. 2645-32-1
Formula C7H5N5S2
M. Wt 223.28
Purity >98%
Synonyms PR619, PR 619

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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