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DUB inhibitor

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Catalog No. A13190

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PR-619 5mg A13190-5

Regular Price: $40.00

Special Price: $36.00

PR-619 10mg A13190-10

Regular Price: $70.00

Special Price: $63.00

PR-619 25mg A13190-25

Regular Price: $100.00

Special Price: $90.00

PR-619 50mg A13190-50

Regular Price: $150.00

Special Price: $135.00

PR-619 10mM * 1mL in DMSO A13190-10mM-D

Regular Price: $80.00

Special Price: $72.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).


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Chemical Information

Catalog Num A13190
Actions Inhibitor
M. Wt 223.28
Formula C7H5N5S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2645-32-1
Synonyms PR619, PR 619

Biological Activity

PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).
Target Value
JOSD2EC50: 1.17μM
SENP6coreEC50: 2.37μM
UCH-L3EC50: 2.95μM
USP4EC50: 3.93μM
USP8EC50: 4.90μM
DEN1EC50: 4.98μM
USP20EC50: 5.10μM
USP28EC50: 6.24μM
USP7EC50: 6.86μM
USP2coreEC50: 7.20μM
USP15EC50: 8.23μM
USP5EC50: 8.61μM
USP47EC50: 8.87μM
UCH-L5EC50: 9.26μM
UCH-L1EC50: 12.8μM
PlproEC50: 14.2μM
PLA2EC50: >50μM
Calpain1EC50: >50μM
CT-LEC50: >50μM
CathepsinDEC50: >50μM
MMP13EC50: >50μM
TrypsinEC50: >50μM


Solubility (25°C)* In vitro DMSO 45 mg/mL (201.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 44.79 mL 223.93 mL 447.87mL
0.5 mM 8.96 mL 44.79 mL 89.57 mL
1 mM 4.48 mL 22.39 mL 44.79 mL
5 mM 0.9 mL 4.48 mL 8.96 mL

*The above data is based on the productmolecular weight 223.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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