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  1. Regorafenib (BAY 73-4506)

    Catalog No. A10250
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    VEGFR inhibitor
    Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Learn More
  2. Flupirtine maleate

    Catalog No. A10251
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    NMDA antagonist
    Non-opioid analgesic with muscle relaxant properties. Learn More
  3. Ostarine (MK-2866, GTx-024)

    Catalog No. A10253
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    Androgen Receptor Modulators
    Ostarine is an androgen receptor modulator (SARM) Learn More
  4. ABT-737

    Catalog No. A10255
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    Bcl-2 Inhibitor
    ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60). Learn More
  5. PD0325901

    Catalog No. A10256
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    MEK inhibitor
    PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2. Learn More
  6. GDC-0449 (Vismodegib)

    Catalog No. A10258
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    Hedgehog antagonist
    GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Learn More
  7. Imatinib (Gleevec)

    Catalog No. A10259
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    PDGFR inhibitor
    Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor. Learn More
  8. ABT-263 (Navitoclax)

    Catalog No. A10022
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    Bcl-2 inhibitor
    ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). it maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.
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  9. MDV3100

    Catalog No. A10562
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    Androgen receptor antagonist
    MDV3100 is androgen-receptor inhibitor. Highly recommended inhibitor in AR research. Learn More
  10. Obatoclax mesylate (GX15-070)

    Catalog No. A10665
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    Bcl-2 Inhibitor
    Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). Learn More
  11. Vandetanib (ZD6474)

    Catalog No. A10963
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    VEGFR inhibitor
    Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. Learn More
  12. RO4929097

    Catalog No. A10802
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    Gamma-secretase inhibitor
    RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. Learn More
  13. PF-2341066 (Crizotinib)

    Catalog No. A10712
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    ALK/ c-Met inhibitor
    PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Learn More
  14. MS-275 (Entinostat)

    Catalog No. A10611
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    HDAC inhibitor
    MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively. Learn More
  15. PTC124 (Ataluren)

    Catalog No. A10758
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    CFTR inhibitor
    PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor. Learn More
  16. Sorafenib Tosylate (Nexavar)

    Catalog No. A10001
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    Raf inhibitor
    Sorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. Learn More
  17. MK-2206 2HCl

    Catalog No. A10003
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    AKT Inhibitor
    MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Learn More
  18. MLN8237 (Alisertib)

    Catalog No. A10004
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    Aurora A Kinase inhibitor
    MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.. Learn More
  19. (-)-Epigallocatechin gallate

    Catalog No. A10005
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    Antioxidant, antiangiogenic, antitumor agent
    (-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea. Learn More
  20. (-)-Huperzine A

    Catalog No. A10006
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    GluR inhibitor
    (-)-Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata. Learn More
  21. LY294002

    Catalog No. A10547
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    PI3K Inhibitor
    LY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor. Learn More
  22. AC220 (Quizartinib)

    Catalog No. A10027
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    FLT3 inhibitor
    AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. Learn More
  23. AZD8055

    Catalog No. A10114
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    mTOR Inhibitor
    AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. Learn More
  24. BEZ235 (NVP-BEZ235, Dactolisib)

    Catalog No. A10133
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    PI3K/mTOR Inhibitor
    BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Learn More
  25. YM155 (Sepantronium Bromide)

    Catalog No. A11002
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    Survivin Inhibitor
    YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity. Learn More
  26. AZD1480

    Catalog No. A10110
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    JAK Inhibitor
    AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. Learn More
  27. Ibuprofen (Advil)

    Catalog No. A10461
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    COX-1 inhibitor
    Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM. Learn More
  28. Hesperadin

    Catalog No. A10448
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    Aurora B Kinase inhibitor
    Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo. Learn More
  29. SP600125

    Catalog No. A10860
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    JNK inhibitor
    SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3. Learn More
  30. Axitinib

    Catalog No. A10103
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    VEGFR inhibitor
    Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). Learn More
  31. SRT1720 HCl

    Catalog No. A10862
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    SIRT1 Activator
    SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1. Learn More
  32. Pelitinib (EKB-569)

    Catalog No. A10706
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    EGFR inhibitor
    Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Learn More
  33. PD 0332991 HCl (Palbociclib)

    Catalog No. A10701
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    CDK 4/6 inhibitor
    PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  34. Perifosine (NSC-639966)

    Catalog No. A10709
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    Akt inhibitor
    Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor. Learn More
  35. Neratinib (HKI-272)

    Catalog No. A10638
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    HER2 inhibitor
    Neratinib (HKI-272) is a tyrosine kinase inhibitor. Learn More
  36. FTY720 (Fingolimod)

    Catalog No. A10408
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    S1P Receptor antagonist
    FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. Learn More
  37. XL184 free base (Cabozantinib)

    Catalog No. A10996
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    VEGFR inhibitor
    XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More
  38. MLN9708

    Catalog No. A10602
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    Proteasome Inhibitor
    MLN9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome. Learn More
  39. Flavopiridol (Alvocidib)

    Catalog No. A10390
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    CDK inhibitor
    Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. Learn More
  40. BKM120 (NVP-BKM120, Buparlisib)

    Catalog No. A11016
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    PI3K Inhibitor‎
    BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. Learn More
  41. PLX4032 (Vemurafenib)

    Catalog No. A10739
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    Raf inhibitor
    PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM. Learn More
  42. GDC-0941 (Pictilisib)

    Catalog No. A10421
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    PI3K inhibitor
    GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. Learn More
  43. CHIR-99021

    Catalog No. A10199
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    GSK-3 Inhibitor
    CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. Learn More
  44. Saracatinib (AZD0530)

    Catalog No. A10108
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    Src/Abl inhibitor
    Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively. Learn More
  45. TAK-875 (Fasiglifam)

    Catalog No. A11018
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    GPR agonist
    TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist. Learn More
  46. CHR2797 (Tosedostat)

    Catalog No. A10208
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    Aminopeptidase inhibitor
    CHR-2797 (Tosedostat) is a novel metalloenzyme inhibitor that exerts antiproliferative effects against a range of tumor cell lines in vitro and in vivo and shows selectivity. Learn More
  47. AZD6482

    Catalog No. A10112
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    PI3K inhibitor
    AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy. Learn More
  48. Masitinib ( AB1010)

    Catalog No. A10558
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  49. Canertinib (CI-1033)

    Catalog No. A10211
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    HER2/ErbB2 inhibitor
    Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM). Learn More
  50. R406 besylate

    Catalog No. A10769
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    Syk Inhibitor
    R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. Learn More

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