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Regorafenib (BAY 73-4506)
Catalog No. A10250 VEGFR inhibitorRegorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Learn More -
Flupirtine maleate
Catalog No. A10251 NMDA antagonistNon-opioid analgesic with muscle relaxant properties. Learn More -
Ostarine (MK-2866, GTx-024)
Catalog No. A10253 Androgen Receptor ModulatorsOstarine is an androgen receptor modulator (SARM) Learn More -
ABT-737
Catalog No. A10255 Bcl-2 InhibitorABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60). Learn More -
PD0325901
Catalog No. A10256 MEK inhibitorPD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2. Learn More -
GDC-0449 (Vismodegib)
Catalog No. A10258 Hedgehog antagonistGDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Learn More -
Imatinib (Gleevec)
Catalog No. A10259 PDGFR inhibitorImatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor. Learn More -
ABT-263 (Navitoclax)
Catalog No. A10022 Bcl-2 inhibitorABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). it maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.Learn More -
MDV3100
Catalog No. A10562 Androgen receptor antagonistMDV3100 is androgen-receptor inhibitor. Highly recommended inhibitor in AR research. Learn More -
Obatoclax mesylate (GX15-070)
Catalog No. A10665 Bcl-2 InhibitorBcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). Learn More -
Vandetanib (ZD6474)
Catalog No. A10963 VEGFR inhibitorVandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. Learn More -
RO4929097
Catalog No. A10802 Gamma-secretase inhibitorRO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. Learn More -
PF-2341066 (Crizotinib)
Catalog No. A10712 ALK/ c-Met inhibitorPF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Learn More -
MS-275 (Entinostat)
Catalog No. A10611 HDAC inhibitorMS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively. Learn More -
PTC124 (Ataluren)
Catalog No. A10758 CFTR inhibitorPTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor. Learn More -
Sorafenib Tosylate (Nexavar)
Catalog No. A10001 Raf inhibitorSorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. Learn More -
MK-2206 2HCl
Catalog No. A10003 AKT InhibitorMK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Learn More -
MLN8237 (Alisertib)
Catalog No. A10004 Aurora A Kinase inhibitorMLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.. Learn More -
(-)-Epigallocatechin gallate
Catalog No. A10005 Antioxidant, antiangiogenic, antitumor agent(-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea. Learn More -
(-)-Huperzine A
Catalog No. A10006 GluR inhibitor(-)-Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata. Learn More -
LY294002
Catalog No. A10547 PI3K InhibitorLY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor. Learn More -
AC220 (Quizartinib)
Catalog No. A10027 FLT3 inhibitorAC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. Learn More -
AZD8055
Catalog No. A10114 mTOR InhibitorAZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. Learn More -
BEZ235 (NVP-BEZ235, Dactolisib)
Catalog No. A10133 PI3K/mTOR InhibitorBEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Learn More -
YM155 (Sepantronium Bromide)
Catalog No. A11002 Survivin InhibitorYM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity. Learn More -
AZD1480
Catalog No. A10110 JAK InhibitorAZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. Learn More -
Ibuprofen (Advil)
Catalog No. A10461 COX-1 inhibitorIbuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM. Learn More -
Hesperadin
Catalog No. A10448 Aurora B Kinase inhibitorHesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo. Learn More -
SP600125
Catalog No. A10860 JNK inhibitorSP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3. Learn More -
Axitinib
Catalog No. A10103 VEGFR inhibitorAxitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). Learn More -
SRT1720 HCl
Catalog No. A10862 SIRT1 ActivatorSRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1. Learn More -
Pelitinib (EKB-569)
Catalog No. A10706 EGFR inhibitorPelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Learn More -
PD 0332991 HCl (Palbociclib)
Catalog No. A10701 CDK 4/6 inhibitorPD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More -
Perifosine (NSC-639966)
Catalog No. A10709 Akt inhibitorPerifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor. Learn More -
Neratinib (HKI-272)
Catalog No. A10638 HER2 inhibitorNeratinib (HKI-272) is a tyrosine kinase inhibitor. Learn More -
FTY720 (Fingolimod)
Catalog No. A10408 S1P Receptor antagonistFTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. Learn More -
XL184 free base (Cabozantinib)
Catalog No. A10996 VEGFR inhibitorXL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More -
MLN9708
Catalog No. A10602 Proteasome InhibitorMLN9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome. Learn More -
Flavopiridol (Alvocidib)
Catalog No. A10390 CDK inhibitorFlavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. Learn More -
BKM120 (NVP-BKM120, Buparlisib)
Catalog No. A11016 PI3K InhibitorBKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. Learn More -
PLX4032 (Vemurafenib)
Catalog No. A10739 Raf inhibitorPLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM. Learn More -
GDC-0941 (Pictilisib)
Catalog No. A10421 PI3K inhibitorGDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. Learn More -
CHIR-99021
Catalog No. A10199 GSK-3 InhibitorCHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. Learn More -
Saracatinib (AZD0530)
Catalog No. A10108 Src/Abl inhibitorSaracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively. Learn More -
TAK-875 (Fasiglifam)
Catalog No. A11018 GPR agonistTAK-875 is a potent, selective, and orally bioavailable GPR40 agonist. Learn More -
CHR2797 (Tosedostat)
Catalog No. A10208 Aminopeptidase inhibitorCHR-2797 (Tosedostat) is a novel metalloenzyme inhibitor that exerts antiproliferative effects against a range of tumor cell lines in vitro and in vivo and shows selectivity. Learn More -
AZD6482
Catalog No. A10112 PI3K inhibitorAZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy. Learn More -
Masitinib ( AB1010)
Catalog No. A10558 c-Kit inhibitorMasitinib (AB1010) is a protein tyrosine kinase inhibitor. Learn More -
Canertinib (CI-1033)
Catalog No. A10211 HER2/ErbB2 inhibitorCanertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM). Learn More -
R406 besylate
Catalog No. A10769 Syk InhibitorR406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. Learn More
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