Raltegravir (MK-0518)

Catalog No.: A10775

HIV-1 integrase inhibitor

Raltegravir (MK-0518)

Raltegravir (MK-0518) Chemical Structure

CAS NO. 518048-05-0

Raltegravir (MK-0518) targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV.

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5 mg

Regular Price: $45.00

Special Price $36.00

10 mg

Regular Price: $65.00

Special Price $52.00

50 mg

Regular Price: $160.00

Special Price $128.00

100 mg

Regular Price: $255.00

Special Price $204.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1

Biological Activity

Raltegravir (MK-0518) targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV.
In vitro (25°C) DMSO 80 mg/mL (180.01 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 7 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.5 mL 112.51 mL 225.02 mL
0.5 mM 4.5 mL 22.5 mL 45 mL
1 mM 2.25 mL 11.25 mL 22.5 mL
5 mM 0.45 mL 2.25 mL 4.5 mL

*The above data is based on the productmolecular weight 444.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10775
Actions Inhibitor
CAS No. 518048-05-0
Formula C20H21FN6O5
M. Wt 444.4
Purity >98%
Synonyms Isentress, MK0518, MK-0518
SMILES CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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