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  1. Regorafenib (BAY 73-4506)

    Catalog No. A10250
    VEGFR inhibitor
    Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Learn More
  2. Flupirtine maleate

    Catalog No. A10251
    NMDA antagonist
    Non-opioid analgesic with muscle relaxant properties. Learn More
  3. Dihydropyrimidinase Inhibitor
    Dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) is a natural antioxidant with good prospects. Learn More
  4. ABT-737

    Catalog No. A10255
    Bcl-2 Inhibitor
    ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60). Learn More
  5. PD0325901

    Catalog No. A10256
    MEK inhibitor
    PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2. Learn More
  6. AZD6244 (Selumetinib)

    Catalog No. A10257
    MEK inhibitor
    AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm. Learn More
  7. GDC-0449 (Vismodegib)

    Catalog No. A10258
    Hedgehog antagonist
    GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Learn More
  8. ABT-263 (Navitoclax)

    Catalog No. A10022
    Bcl-2 inhibitor
    ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w).ABT-263 maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.
    Learn More
  9. MDV3100

    Catalog No. A10562
    Androgen receptor antagonist
    MDV3100 is androgen-receptor inhibitor. Highly recommended inhibitor in AR research. Learn More
  10. Bcl-2 Inhibitor
    Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). Learn More
  11. RO4929097

    Catalog No. A10802
    Gamma-secretase inhibitor
    RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. Learn More
  12. MS-275 (Entinostat)

    Catalog No. A10611
    HDAC inhibitor
    MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively. Learn More
  13. Dehydrogenase inhibitor
    Mono-ammonium glycyrrhizinate(AMGZ) is a unique product derived from Licorice root and has an extremely sweet taste. Learn More
  14. PTC124 (Ataluren)

    Catalog No. A10758
    CFTR inhibitor
    PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor. Learn More
  15. INCB018424 (Ruxolitinib)

    Catalog No. A11041
    JAK1/2 Inhibitor
    INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; Learn More
  16. Sorafenib (Nexavar)

    Catalog No. A10001
    Raf inhibitor
    Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. Learn More
  17. PLX-4720

    Catalog No. A10002
    Raf inhibitor
    PLX-4720 is a B-raf inhibitor with IC50 of 160 nM. Learn More
  18. MK-2206 2HCl

    Catalog No. A10003
    AKT Inhibitor
    MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Learn More
  19. MLN8237 (Alisertib)

    Catalog No. A10004
    Aurora A Kinase inhibitor
    MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.. Learn More
  20. Antioxidant, antiangiogenic, antitumor agent
    (-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea. Learn More
  21. LY294002

    Catalog No. A10547
    PI3K Inhibitor
    LY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor. Learn More
  22. AC220 (Quizartinib)

    Catalog No. A10027
    FLT3 inhibitor
    AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. Learn More
  23. PD98059

    Catalog No. A10705
    MEK Inhibitor
    PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Learn More
  24. AZD8055

    Catalog No. A10114
    mTOR Inhibitor
    AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. Learn More
  25. Survivin Inhibitor
    YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity. Learn More
  26. AZD1480

    Catalog No. A10110
    JAK Inhibitor
    AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. Learn More
  27. Ibuprofen (Advil)

    Catalog No. A10461
    COX-1 inhibitor
    Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM. Learn More
  28. Hesperadin

    Catalog No. A10448
    Aurora B Kinase inhibitor
    Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo. Learn More
  29. SP600125

    Catalog No. A10860
    JNK inhibitor
    SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3. Learn More
  30. Axitinib

    Catalog No. A10103
    VEGFR inhibitor
    Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). Learn More
  31. SRT1720 HCl

    Catalog No. A10862
    SIRT1 Activator
    SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1. Learn More
  32. Pelitinib (EKB-569)

    Catalog No. A10706
    EGFR inhibitor
    Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Learn More
  33. FTY720 (Fingolimod)

    Catalog No. A10408
    S1P Receptor antagonist
    FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. Learn More
  34. VEGFR inhibitor
    XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More
  35. MLN9708

    Catalog No. A10602
    Proteasome Inhibitor
    MLN9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome. Learn More
  36. Flavopiridol (Alvocidib)

    Catalog No. A10390
    CDK inhibitor
    Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. Learn More
  37. PI3K Inhibitor‎
    BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. Learn More
  38. ABT-888 (Veliparib)

    Catalog No. A10026
    PARP inhibitor
    ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor. Learn More
  39. PLX4032 (Vemurafenib)

    Catalog No. A10739
    Raf inhibitor
    PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM. Learn More
  40. GDC-0941 (Pictilisib)

    Catalog No. A10421
    PI3K inhibitor
    GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. Learn More
  41. Saracatinib (AZD0530)

    Catalog No. A10108
    Src/Abl inhibitor
    Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively. Learn More
  42. TAK-875 (Fasiglifam)

    Catalog No. A11018
    GPR agonist
    TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist. Learn More
  43. AZD6482

    Catalog No. A10112
    PI3K inhibitor
    AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy. Learn More
  44. R406 besylate

    Catalog No. A10769
    Syk Inhibitor
    R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. Learn More
  45. R406 (Tamatinib)

    Catalog No. A10770
    Syk Inhibitor
    R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling. Learn More
  46. BI 2536

    Catalog No. A10134
    PLK inhibitor
    BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations. Learn More
  47. Pomalidomide (CC-4047)

    Catalog No. A10743
    TNF-alpha inhibitor
    Pomalidomide is a derivative of thalidomide and acts as an immunomodulator. Learn More
  48. Trichostatin-A (TSA)

    Catalog No. A10947
    HDAC Inhibitor
    Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM. Learn More
  49. Temsirolimus (Torisel)

    Catalog No. A10906
    mTOR inhibitor
    Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. Learn More

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