renin-angiotensin-aldosterone system (RAAS)

Catalog No.Inhibitor Name AT1 receptorAT2 receptorACEReninRAAS
A11123Aliskiren Hemifumarate
***
A10175Candesartan
****
A10351Enalaprilat Dihydrate
***
***
****
A10477Irbesartan
***
A13201PD123319
*
A10710Perindopril Erbumine
***
A10176Candesartan Cilexetil
****
A10778Ramipril
**
A11738Captopril
*
A16420Azilsartan Medoxomil
**
A13747Eprosartan Mesylate
****
A11775Azilsartan
**
A10905Telmisartan
A10123Benazepril HCl
A10350Enalapril Maleate
A11615Olmesartan Medoxomil
A11747Cilazapril Monohydrate
A11876Lisinopril
A11745Moexipril HCl
A11749Temocapril
A11736Quinapril HCl
A14206LCZ696
A11748Fosinopril Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. AVE 0991

    Catalog No. A20997
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    angiotensin-(1-7) receptor agonist
    AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM. Learn More
  2. Fimasartan

    Catalog No. A17477
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    non-peptide angiotensin II receptor antagonist
    Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. Learn More
  3. Azilsartan Medoxomil

    Catalog No. A16420
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    angiotensin II receptor type 1 antagonist
    Azilsartan medoxomil is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. Learn More
  4. Ramipril

    Catalog No. A10778
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    ACE inhibitor
    Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM. Learn More
  5. BIBS39

    Catalog No. A14154
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    angiotensin II receptor antagonist
    BIBS39 is a nonpeptide angiotensin II (AII) receptor antagonists that displaced [125I] AII from its specific binding sites with a K(i) value of 29 +/- 7 nM for the AII subtype I (AT1) receptor and a K(i) value of 480 +/- 110 nM for the AII subtype 2 (AT2) receptor. Learn More
  6. Azilsartan medoxomil monopotassium

    Catalog No. A20860
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    angiotensin II receptor type 1 antagonist
    Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. Learn More
  7. Tasosartan

    Catalog No. A10891
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    Angiotensin II receptor antagonist
    Tasosartan is an angiotensin II receptor antagonist. Learn More
  8. Eprosartan mesylate

    Catalog No. A13747
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    Eprosartan (mesylate) is a competitive AT1 receptor antagonist with IC50 values ranging from 1.4 – 3.9 nM and an elimination half-life of five to seven hours. Learn More
  9. Telmisartan

    Catalog No. A10905
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    AT1 Antagonist
    Telmisartan is an angiotensin II receptor antagonist that inhibits the angiotensin II AT1 receptor. Learn More
  10. Zofenopril calcium

    Catalog No. A12769
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    ACE inhibitor
    Zofenopril calcium is an angiotensin-converting enzyme ACE inhibitor. Learn More
  11. Losartan

    Catalog No. A17510
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    Angiotensin II receptor antagonist
    Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. Learn More
  12. H-Val-Pro-Pro-OH

    Catalog No. A18868
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    ACE inhibitor
    H-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM. Learn More
  13. Zofenopril

    Catalog No. A13615
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    ACE inhibitor
    Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 81 μM. Learn More
  14. PD 123319 trifluoroacetate salt

    Catalog No. A21529
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    AT2 angiotensin II receptor antagonist
    PD 123319 trifluoroacetate salt is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. Learn More
  15. Azilsartan D5

    Catalog No. A21600
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    angiotensin II type 1 receptor antagonist
    Azilsartan D5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist. Learn More
  16. Losartan (D4 Carboxylic Acid)

    Catalog No. A21578
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    angiotensin II receptor antagonist
    Losartan D4 Carboxylic Acid is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist. Learn More
  17. CGP-42112

    Catalog No. A21575
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    Angiotensin-II subtype 2 receptor(AT2 R) agonist
    CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist. Learn More
  18. Lisinopril

    Catalog No. A21064
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    angiotensin-converting enzyme inhibitor
    Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. Learn More
  19. Sparsentan

    Catalog No. A20879
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    angiotensin II and endothelin A receptor antagonist
    Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively. Learn More
  20. Imidaprilate

    Catalog No. A20003
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    ACE inhibitor
    Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease. Learn More
  21. Valsartan

    Catalog No. A10962
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    angiotensin II receptor antagonist
    Valsartan (CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure. Learn More
  22. SL910102

    Catalog No. A13591
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    Angiotensin AT1 receptor antagonist
    SL910102 is a nonpeptide angiotensin AT1 receptor antagonist. Learn More
  23. Imidapril (Tanatril)

    Catalog No. A11867
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    Imidapril (Tanatril) is an inhibitor of angiotensin converting enzyme (ACE). Learn More
  24. Lisinopril (Zestril)

    Catalog No. A11876
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    Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes. Learn More
  25. Eprosartan

    Catalog No. A11121
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    AT1 receptor antagonist
    Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Learn More
  26. Olmesartan (RNH6270, CS-088)

    Catalog No. A10670
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    Olmesartan is an angiotensin II receptor antagonist indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. Learn More
  27. Olmesartan medoxomil

    Catalog No. A11615
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    Olmesartan medoxomil is an angiotensin II receptor antagonist used to treat high blood pressure. Olmesartan works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle. By blocking the binding rather than the synthesis of angiotensin II, olmesartan inhibits the negative regulatory feedback on renin secretion. Learn More
  28. Azilsartan (TAK-536)

    Catalog No. A11775
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    AT1 Receptor Blocker
    Azilsartan (TAK-536) is an angiotensin II receptor antagonist used in the treatment of hypertension. Learn More
  29. Captopril

    Catalog No. A11738
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    Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Learn More
  30. Moxonidine

    Catalog No. A11317
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    Moxonidine is a new-generation centrally-acting antihypertensive drug. It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure. In addition, it demonstrates favourable effects on parameters of the insulin resistance syndrome, apparently independent of blood pressure reduction. Learn More
  31. Fosinopril sodium

    Catalog No. A11748
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    ACE inhibitor
    Fosinopril is an angiotensin converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of chronic heart failure. Learn More
  32. Perindopril Erbumine (Aceon)

    Catalog No. A10710
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    Perindopril Butylamine Salt is an angiotensin-converting enzyme (ACE) inhibitor. Learn More
  33. Captopril disulfide

    Catalog No. A13521
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    LTA4 hydrolase inhibitor
    Captopril Disulfide is a reversible and competitive inhibitor of LTA4 hydrolase (IC50=11 M). Captopril has been shown to be an of angiotensin converting enzyme-1 (ACE1), but not ACE2(IC50 = 22 nM). Learn More
  34. Quinapril hydrochloride

    Catalog No. A11736
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    Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Learn More
  35. Enalapril maleate

    Catalog No. A10350
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    ACE inhibitor
    Enalapril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension and some types of chronic heart failure. Learn More
  36. Candesartan cilexetil (Atacand)

    Catalog No. A10176
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    Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Learn More
  37. Aliskiren (CGP 60536)

    Catalog No. A11616
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    Renin inhibitor
    Aliskiren is an orally active, synthetic nonpeptide renin inhibitor. Learn More
  38. Enalaprilat dihydrate

    Catalog No. A10351
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    RAAS inhibitor
    Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor and was developed partly to overcome these limitations of captopril. Learn More
  39. PD 123319 ditrifluoroacetate

    Catalog No. A13201
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    angiotensin AT2 receptor antagonist
    PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively. Learn More
  40. Angiotensin I (human, mouse, rat)

    Catalog No. A14859
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    Angiotensin I is formed by the action of renin on angiotensinogen. Learn More
  41. Irbesartan (Avapro)

    Catalog No. A10477
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    AT1 antagonist
    Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Learn More
  42. Rosuvastatin

    Catalog No. A11122
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    HMG-CoA reductase inhibitor
    Rosuvastatin is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. Learn More
  43. Clinofibrate

    Catalog No. A11184
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    HMG-CoA Reductase inhibitor

    Clinofibrate is a lipid clearing agent that appears to modify lipid metabolism, diminishing the steroid induced accumulation of lipids within osteocytes. It also can effectively reduce the plasma fibrinogen level.

    Learn More
  44. Benazepril HCl

    Catalog No. A10123
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    RAAS inhibitor

    Benazepril hydrochloride is a non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

    Learn More
  45. Candesartan (Atacand)

    Catalog No. A10175
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    RAAS antagonist
    Candesartan is an angiotensin receptor blocker (also called an angiotensin-II receptor antagonist or an AIIRA). Learn More
  46. Temocapril

    Catalog No. A11749
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    ACE inhibitor
    Temocapril is an ACE inhibitor. Learn More
  47. MLN-4760

    Catalog No. A16884
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    ACE2 inhibitor
    MLN-4760 is an angiotensin-converting (ACE2) inhibitor. In huMNCs, MLN-4760-B detected 63% ACE2 with 28-fold selectivity over ACE. Learn More
  48. Aliskiren hemifumarate

    Catalog No. A11123
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    renin inhibitor
    Aliskiren hemifumarate is a hemifumarate salt form of Aliskiren, which is a direct renin inhibitor approved for the treatment of essential hypertension. Learn More
  49. Angiotensin (1-7)

    Catalog No. A14862
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    Angiotensin (1-7) is an endogenous peptide fragment that can be produced from Ang I or Ang II via endo- or carboxy-peptidases respectively. Learn More
  50. Angiotensin II

    Catalog No. A14863
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    Angiotensin II (Ang II) is an octapeptide hormone that plays a central role in cardiovascular homeostasis. Learn More

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