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$0.00 renin-angiotensin-aldosterone system (RAAS)
| Catalog No. | Inhibitor Name | AT1 receptor | AT2 receptor | ACE | Renin | RAAS |
|---|---|---|---|---|---|---|
| A11123 | Aliskiren Hemifumarate | *** | ||||
| A10175 | Candesartan | **** | ||||
| A10351 | Enalaprilat Dihydrate | *** | *** | **** | ||
| A10477 | Irbesartan | *** | ||||
| A13201 | PD123319 | * | ||||
| A10710 | Perindopril Erbumine | *** | ||||
| A10176 | Candesartan Cilexetil | **** | ||||
| A10778 | Ramipril | ** | ||||
| A11738 | Captopril | * | ||||
| A16420 | Azilsartan Medoxomil | ** | ||||
| A13747 | Eprosartan Mesylate | **** | ||||
| A11775 | Azilsartan | ** | ||||
| A10905 | Telmisartan | |||||
| A10123 | Benazepril HCl | |||||
| A10350 | Enalapril Maleate | |||||
| A11615 | Olmesartan Medoxomil | |||||
| A11747 | Cilazapril Monohydrate | |||||
| A11876 | Lisinopril | |||||
| A11745 | Moexipril HCl | |||||
| A11749 | Temocapril | |||||
| A11736 | Quinapril HCl | |||||
| A14206 | LCZ696 | |||||
| A11748 | Fosinopril Sodium |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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AVE 0991
Catalog No. A20997 angiotensin-(1-7) receptor agonistAVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM. Learn More -
BIBS39
Catalog No. A14154 angiotensin II receptor antagonistBIBS39 is a nonpeptide angiotensin II (AII) receptor antagonists that displaced [125I] AII from its specific binding sites with a K(i) value of 29 +/- 7 nM for the AII subtype I (AT1) receptor and a K(i) value of 480 +/- 110 nM for the AII subtype 2 (AT2) receptor. Learn More -
Ramipril
Catalog No. A10778 ACE inhibitorRamipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM. Learn More -
Azilsartan Medoxomil
Catalog No. A16420 angiotensin II receptor type 1 antagonistAzilsartan medoxomil is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. Learn More -
Tasosartan
Catalog No. A10891 Angiotensin II receptor antagonistTasosartan is an angiotensin II receptor antagonist. Learn More -
Eprosartan mesylate
Catalog No. A13747 Eprosartan (mesylate) is a competitive AT1 receptor antagonist with IC50 values ranging from 1.4 – 3.9 nM and an elimination half-life of five to seven hours. Learn More -
Telmisartan
Catalog No. A10905 AT1 AntagonistTelmisartan is an angiotensin II receptor antagonist that inhibits the angiotensin II AT1 receptor. Learn More -
Fimasartan
Catalog No. A17477 non-peptide angiotensin II receptor antagonistFimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. Learn More -
Zofenopril calcium
Catalog No. A12769 ACE inhibitorZofenopril calcium is an angiotensin-converting enzyme ACE inhibitor. Learn More -
Imidapril (Tanatril)
Catalog No. A11867 Imidapril (Tanatril) is an inhibitor of angiotensin converting enzyme (ACE). Learn More -
Lisinopril (Zestril)
Catalog No. A11876 Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes. Learn More -
Perindopril Erbumine (Aceon)
Catalog No. A10710 Perindopril Butylamine Salt is an angiotensin-converting enzyme (ACE) inhibitor. Learn More -
Losartan
Catalog No. A17510 Angiotensin II receptor antagonistLosartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. Learn More -
H-Val-Pro-Pro-OH
Catalog No. A18868 ACE inhibitorH-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM. Learn More -
Zofenopril
Catalog No. A13615 ACE inhibitorZofenopril is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 81 μM. Learn More -
Fosinopril sodium
Catalog No. A11748 ACE inhibitorFosinopril is an angiotensin converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of chronic heart failure. Learn More -
Valsartan
Catalog No. A10962 angiotensin II receptor antagonistValsartan (CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure. Learn More -
Azilsartan D5
Catalog No. A21600 angiotensin II type 1 receptor antagonistAzilsartan D5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist. Learn More -
Losartan (D4 Carboxylic Acid)
Catalog No. A21578 angiotensin II receptor antagonistLosartan D4 Carboxylic Acid is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist. Learn More -
CGP-42112
Catalog No. A21575 Angiotensin-II subtype 2 receptor(AT2 R) agonistCGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist. Learn More -
Eprosartan
Catalog No. A11121 AT1 receptor antagonistEprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Learn More -
Lisinopril
Catalog No. A21064 angiotensin-converting enzyme inhibitorLisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. Learn More -
Olmesartan (RNH6270, CS-088)
Catalog No. A10670 Olmesartan is an angiotensin II receptor antagonist indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. Learn More -
Olmesartan medoxomil
Catalog No. A11615 Olmesartan medoxomil is an angiotensin II receptor antagonist used to treat high blood pressure. Olmesartan works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle. By blocking the binding rather than the synthesis of angiotensin II, olmesartan inhibits the negative regulatory feedback on renin secretion. Learn More -
Sparsentan
Catalog No. A20879 angiotensin II and endothelin A receptor antagonistSparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively. Learn More -
Azilsartan medoxomil monopotassium
Catalog No. A20860 angiotensin II receptor type 1 antagonistAzilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. Learn More -
Azilsartan (TAK-536)
Catalog No. A11775 AT1 Receptor BlockerAzilsartan (TAK-536) is an angiotensin II receptor antagonist used in the treatment of hypertension. Learn More -
Imidaprilate
Catalog No. A20003 ACE inhibitorImidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease. Learn More -
Captopril
Catalog No. A11738 Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Learn More -
Moxonidine
Catalog No. A11317 Moxonidine is a new-generation centrally-acting antihypertensive drug. It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure. In addition, it demonstrates favourable effects on parameters of the insulin resistance syndrome, apparently independent of blood pressure reduction. Learn More -
SL910102
Catalog No. A13591 Angiotensin AT1 receptor antagonistSL910102 is a nonpeptide angiotensin AT1 receptor antagonist. Learn More -
MLN-4760
Catalog No. A16884 ACE2 inhibitorMLN-4760 is an angiotensin-converting (ACE2) inhibitor. In huMNCs, MLN-4760-B detected 63% ACE2 with 28-fold selectivity over ACE. Learn More -
Captopril disulfide
Catalog No. A13521 LTA4 hydrolase inhibitorCaptopril Disulfide is a reversible and competitive inhibitor of LTA4 hydrolase (IC50=11 M). Captopril has been shown to be an of angiotensin converting enzyme-1 (ACE1), but not ACE2(IC50 = 22 nM). Learn More -
EXP-3174
Catalog No. A15451 AT1 receptor antagonistEXP-3174 is a potent and selective noncompetitive AT1 receptor antagonist with IC50 value of 37 nM. Learn More -
Spinorphin
Catalog No. A15314 Enkephalin-degrading and ACE inhibitorSpinorphin is an endogenous factor that exhibits inhibitory effects on enkephalin-degrading enzymes. Learn More -
VTP-27999 2,2,2-trifluoroacetate
Catalog No. A15281 Renin inhibitorVTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. Learn More -
Angiotensin 1/2 + A (2 - 8)
Catalog No. A14888 Angiotensin 1/2 + A (2 - 8), potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Learn More -
Angiotensin 1/2 (1-6)
Catalog No. A14887 Angiotensin 1/2 (1-6) is a peptide that contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. Learn More -
Enalapril maleate
Catalog No. A10350 ACE inhibitorEnalapril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension and some types of chronic heart failure. Learn More -
Candesartan (Atacand)
Catalog No. A10175 RAAS antagonistCandesartan is an angiotensin receptor blocker (also called an angiotensin-II receptor antagonist or an AIIRA). Learn More -
Benazepril HCl
Catalog No. A10123 RAAS inhibitorBenazepril hydrochloride is a non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.
Learn More -
Clinofibrate
Catalog No. A11184 HMG-CoA Reductase inhibitorClinofibrate is a lipid clearing agent that appears to modify lipid metabolism, diminishing the steroid induced accumulation of lipids within osteocytes. It also can effectively reduce the plasma fibrinogen level.
Learn More -
Rosuvastatin
Catalog No. A11122 HMG-CoA reductase inhibitorRosuvastatin is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. Learn More -
Irbesartan (Avapro)
Catalog No. A10477 AT1 antagonistIrbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Learn More -
Aliskiren (CGP 60536)
Catalog No. A11616 Renin inhibitorAliskiren is an orally active, synthetic nonpeptide renin inhibitor. Learn More -
Candesartan cilexetil (Atacand)
Catalog No. A10176 Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Learn More -
Quinapril hydrochloride
Catalog No. A11736 Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Learn More -
Moexipril hydrochloride
Catalog No. A11745 Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) which is used for the treatment of hypertension and congestive heart failure. Learn More -
Cilazapril monohydrate
Catalog No. A11747 ACE inhibitorCilazapril is a pyridazine angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. Learn More
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