renin-angiotensin-aldosterone system (RAAS)

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  1. RAAS inhibitor

    Benazepril hydrochloride is a non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

  2. RAAS antagonist

    Candesartan is an angiotensin receptor blocker (also called an angiotensin-II receptor antagonist or an AIIRA).
  3. Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
  4. ACE inhibitor

    Enalapril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension and some types of chronic heart failure.
  5. RAAS inhibitor

    Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor and was developed partly to overcome these limitations of captopril.
  6. AT1 antagonist

    Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
  7. Olmesartan is an angiotensin II receptor antagonist indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
  8. Perindopril Butylamine Salt is an angiotensin-converting enzyme (ACE) inhibitor.
  9. ACE inhibitor

    Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
  10. Angiotensin II receptor antagonist

    Tasosartan is an angiotensin II receptor antagonist.
  11. AT1 Antagonist

    Telmisartan is an angiotensin II receptor antagonist that inhibits the angiotensin II AT1 receptor.
  12. angiotensin II receptor antagonist

    Valsartan (CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.
  13. AT1 receptor antagonist

    Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure.
  14. HMG-CoA reductase inhibitor

    Rosuvastatin is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease.
  15. renin inhibitor

    Aliskiren hemifumarate is a hemifumarate salt form of Aliskiren, which is a direct renin inhibitor approved for the treatment of essential hypertension.
  16. HMG-CoA Reductase inhibitor

    Clinofibrate is a lipid clearing agent that appears to modify lipid metabolism, diminishing the steroid induced accumulation of lipids within osteocytes. It also can effectively reduce the plasma fibrinogen level.

  17. ACE inhibitor/Beta blocker

    Moxonidine is a new-generation centrally-acting antihypertensive drug. It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure. In addition, it demonstrates favourable effects on parameters of the insulin resistance syndrome, apparently independent of blood pressure reduction.
  18. Renin inhibitor

    VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. Ic50 value: Target: Renin
  19. Olmesartan medoxomil is an angiotensin II receptor antagonist used to treat high blood pressure. Olmesartan works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle. By blocking the binding rather than the synthesis of angiotensin II, olmesartan inhibits the negative regulatory feedback on renin secretion.
  20. Renin inhibitor

    Aliskiren is an orally active, synthetic nonpeptide renin inhibitor.
  21. Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I.
  22. Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure.
  23. Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) which is used for the treatment of hypertension and congestive heart failure.
  24. ACE inhibitor

    Cilazapril is a pyridazine angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure.
  25. ACE inhibitor

    Fosinopril is an angiotensin converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of chronic heart failure.
  26. ACE inhibitor

    Temocapril is an ACE inhibitor.
  27. AT1 Receptor Blocker

    Azilsartan (TAK-536) is an angiotensin II receptor antagonist used in the treatment of hypertension.
  28. Imidapril (Tanatril) is an inhibitor of angiotensin converting enzyme (ACE).
  29. Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
  30. ACE inhibitor

    Zofenopril calcium is an angiotensin-converting enzyme ACE inhibitor.
  31. angiotensin AT2 receptor antagonist

    PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
  32. LTA4 hydrolase inhibitor

    Captopril Disulfide is a reversible and competitive inhibitor of LTA4 hydrolase (IC50=11 M). Captopril has been shown to be an of angiotensin converting enzyme-1 (ACE1), but not ACE2(IC50 = 22 nM).
  33. Angiotensin AT1 receptor antagonist

    SL910102 is a nonpeptide angiotensin AT1 receptor antagonist.
  34. ACE inhibitor

    Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 81 μM.
  35. Eprosartan (mesylate) is a competitive AT1 receptor antagonist with IC50 values ranging from 1.4 ?€? 3.9 nM and an elimination half-life of five to seven hours.
  36. Renin inhibitor

    VTP-27999 HCl is a potent inhibitor of renin with IC50 value of 0.3 nM for human renin.
  37. angiotensin II receptor antagonist

    BIBS39 is a nonpeptide angiotensin II (AII) receptor antagonists that displaced [125I] AII from its specific binding sites with a K(i) value of 29 +/- 7 nM for the AII subtype I (AT1) receptor and a K(i) value of 480 +/- 110 nM for the AII subtype 2 (AT2) receptor.
  38. angiotensin receptor-neprilysin inhibitor

    LCZ696 is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure.
  39. Angiotensin I is formed by the action of renin on angiotensinogen.
  40. Angiotensin (1-7) is an endogenous peptide fragment that can be produced from Ang I or Ang II via endo- or carboxy-peptidases respectively.
  41. Angiotensin II (Ang II) is an octapeptide hormone that plays a central role in cardiovascular homeostasis.
  42. Angiotensin III is a hexapeptide formed as a result of a cleavage at the N-terminus of Angiotensin II, a key factor in the Renin-Angiotensin-Aldosterone (RAAS) system by angiotensinases located in red blood cells and the vascular beds of most tissues.
  43. Angiotensin 1/2 (1-9) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS) containing the amino acids 1-9 that are converted from Angiotensin I/II peptide.
  44. Acetyl Angiotensinogen (1-14),porcine, The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor.
  45. Angiotensin 1/2 (1-5) is a peptide that contains the amino acids 1-5 and is converted from Angiotensin I/II.
  46. Angiotensin 1/2 (1-6) is a peptide that contains the amino acids 1-6 and is converted from Angiotensin I/II peptide.
  47. Angiotensin 1/2 + A (2 - 8), potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II.
  48. BNP (1-32), human is a brain natriuretic peptide secreted by the human heart in response to cardiac volume or pressure.
  49. Renin inhibitor

    VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
  50. Enkephalin-degrading and ACE inhibitor

    Spinorphin is an endogenous factor that exhibits inhibitory effects on enkephalin-degrading enzymes.

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