RI-1

Catalog No.: A13187

RAD51 Inhibitor II

RI-1

RI-1 Chemical Structure

CAS NO. 415713-60-9

RI-1 is a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA.

Availability: In stock

Package Price Qty
5 mg
$75.00
10 mg
$130.00
25 mg
$260.00
50 mg
$490.00
10mM * 1mL in DMSO
$83.00
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Biological Activity

RI-1 is a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA.
Targets
RAD51
<30 μM
In vitro DMSO 50 mg/mL (138.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.65 mL 138.27 mL 276.54 mL
0.5 mM 5.53 mL 27.65 mL 55.31 mL
1 mM 2.77 mL 13.83 mL 27.65 mL
5 mM 0.55 mL 2.77 mL 5.53 mL

*The above data is based on the productmolecular weight 361.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13187
Actions Inhibitor
M. Wt 361.61
Formula C14H11Cl3N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 415713-60-9
Synonyms RI1?? RI 1
SMILES C1COCCN1C2=C(C(=O)N(C2=O)C3=CC(=C(C=C3)Cl)Cl)Cl

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