ROCK inhibitor

Catalog No.: A15225
ROCK inhibitor
ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively.
Grouped product items
Product Name Price Stock Qty
ROCK inhibitor 5mg
$300.00
In stock
ROCK inhibitor 10mg
$450.00
In stock
ROCK inhibitor 50mg
$1,100.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's ROCK inhibitor has been cited by 2 publications
  • Delia Talpan, .et al. , Int J Mol Sci, 2023, Jan 11;24(2):1461 PMID: 36674976
  • Nina Seidelmann, .et al. , J Cell Mol Med, 2021, Oct;25(20):9647-9659 PMID: 34486211
  • Biological Activity
    Discription ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A15225
    Formula C18H13ClF2N6O
    Molecular Weight 402.79
    CAS Number 867017-68-3
    SMILES CC1=CNC2=NC=CC(=C12)OC3=C(C=C(C=C3F)NC4=CC(=NC(=N4)N)Cl)F
    Synonyms Rho-kinase inhibitor, Rho Kinase Inhibitor, ROCK
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 77 mg/mL (191.16 mM)
    Water Insoluble
    Ethanol 2 mg/mL (4.96 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.83 mL 124.13 mL 248.27 mL
    0.5 mM 4.97 mL 24.83 mL 49.65 mL
    1 mM 2.48 mL 12.41 mL 24.83 mL
    5 mM 0.5 mL 2.48 mL 4.97 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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