Saxagliptin (BMS-477118)

Catalog No.: A11109

DPP-4 Inhibitor

Saxagliptin (BMS-477118)

Saxagliptin (BMS-477118) Chemical Structure

CAS NO. 361442-04-8

Saxagliptin (BMS-477118) is a new dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 50 nM.

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100 mg
10mM * 1mL in DMSO
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  • OHE El-Shoubashy, .et al. Comparative study of HPLC-DAD and HPTLC for the simultaneous determination of a new multitarget antidiabetic ternary mixture in combined tablets, JPC, 2020, 33, 59-70
  • Sato T, .et al. DPP8 is a novel therapeutic target for multiple myeloma, Sci Rep, 2019, Dec 2;9(1):18094 PMID: 31792328
  • Chintan N. Koyani, .et al. Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes, Front Physiol, 2018, 9: 1622 PMID: 30487758
  • Koyani CN, .et al. Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure, Biochem Pharmacol, 2016, Dec 1;145:64-80 PMID: 28859968

Biological Activity

Saxagliptin (BMS-477118) is a new dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 50 nM.
26 nM
In vitro (25°C) DMSO 62 mg/mL (196.57 mM)
Water 62 mg/mL (196.57 mM)
Ethanol 24 mg/mL (76.09 mM)
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.71 mL 158.53 mL 317.06 mL
0.5 mM 6.34 mL 31.71 mL 63.41 mL
1 mM 3.17 mL 15.85 mL 31.71 mL
5 mM 0.63 mL 3.17 mL 6.34 mL

*The above data is based on the productmolecular weight 315.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11109
Actions Inhibitor
CAS No. 361442-04-8
Formula C18H25N3O2
M. Wt 315.4
Purity >98%
Synonyms BMS-477118,Onglyza
SMILES C1[[email protected]@H]2C[[email protected]@H]2N([[email protected]@H]1C#N)C(=O)[[email protected]](C34CC5CC(C3)CC(C5)(C4)O)N

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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