SB-408124

Catalog No.: A11567

OX Receptor Antagonist

SB-408124

SB-408124 Chemical Structure

CAS NO. 288150-92-5

SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $80.00

Special Price $72.00

25 mg

Regular Price: $160.00

Special Price $144.00

50 mg

Regular Price: $280.00

Special Price $252.00

100 mg

Regular Price: $500.00

Special Price $450.00

10mM * 1mL in DMSO

Regular Price: $88.00

Special Price $79.20

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.
Targets
OX1 (membrane) OX1 (whole cell)
27 nM(Ki)57 nM(Ki)
In vitro (25°C) DMSO 36 mg/mL (101.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.06 mL 140.3 mL 280.61 mL
0.5 mM 5.61 mL 28.06 mL 56.12 mL
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL

*The above data is based on the productmolecular weight 356.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11567
Actions Antagonist
M. Wt 356.37
Formula C19H18F2N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 288150-92-5
Synonyms SB408124, SB 408124
SMILES CC1=NC2=C(C=C(C=C2C(=C1)NC(=O)NC3=CC=C(C=C3)N(C)C)F)F

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy SB-408124 | SB-408124 Supplier | purchase SB-408124 | SB-408124 cost | SB-408124 manufacturer | order SB-408124 | SB-408124 distributor | buy 288150-92-5| 288150-92-5 Supplier | purchase 288150-92-5 | 288150-92-5 cost | 288150-92-5 manufacturer | order 288150-92-5 | 288150-92-5 distributor
Rewards