SB 743921

Catalog No.: A10828

KSP Inhibitor

SB 743921

SB 743921 Chemical Structure

CAS NO. 940929-33-9

SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Biological Activity

SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.
Target Value
KSP(MX1cells)IC50: 0.06nM
KSP(Colo205cells)IC50: 0.07nM
KSPki: 0.1nM
KSP(SKOV3cells)IC50: 0.2nM
KSP(MV522cells)IC50: 1.7nM
KSP(P388cells)IC50: 14.4nM
In vitro (25°C) DMSO 103 mg/mL (186.08 mM)
Water 20 mg/mL (36.13 mM)
Ethanol 103 mg/mL (186.08 mM)
In vivo Saline pH5.0 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.07 mL 90.33 mL 180.67 mL
0.5 mM 3.61 mL 18.07 mL 36.13 mL
1 mM 1.81 mL 9.03 mL 18.07 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10828
Actions Inhibitor
CAS No. 940929-33-9
Formula C31H33N2O3.HCl
M. Wt 553.5
Purity >98%
Synonyms SB-743921, SB743921
SMILES CC1=CC=C(C=C1)C(=O)N(CCCN)[[email protected]@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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