Biological Activity
SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.
Targets
Target | Value |
---|---|
KSP(MX1cells) | IC50: 0.06nM |
KSP(Colo205cells) | IC50: 0.07nM |
KSP | ki: 0.1nM |
KSP(SKOV3cells) | IC50: 0.2nM |
KSP(MV522cells) | IC50: 1.7nM |
KSP(P388cells) | IC50: 14.4nM |
In vitro (25°C) | DMSO | 103 mg/mL (186.08 mM) | |
Water | 20 mg/mL (36.13 mM) | ||
Ethanol | 103 mg/mL (186.08 mM) | ||
In vivo | Saline pH5.0 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.07 mL | 90.33 mL | 180.67 mL |
0.5 mM | 3.61 mL | 18.07 mL | 36.13 mL |
1 mM | 1.81 mL | 9.03 mL | 18.07 mL |
5 mM | 0.36 mL | 1.81 mL | 3.61 mL |
*The above data is based on the productmolecular weight 553.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10828 |
---|---|
Actions | Inhibitor |
CAS No. | 940929-33-9 |
Formula | C31H33N2O3.HCl |
M. Wt | 553.5 |
Purity | >98% |
Synonyms | SB-743921, SB743921 |
SMILES | CC1=CC=C(C=C1)C(=O)N(CCCN)[[email protected]@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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