SB 743921

Catalog No.: A10828

KSP Inhibitor

SB 743921 Chemical Structure

CAS NO. 940929-33-9

SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$220.00
50 mg
$670.00
100 mg
$950.00
10mM * 1mL in DMSO
$225.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.
Targets
Target Value
KSP(MX1cells)IC50: 0.06nM
KSP(Colo205cells)IC50: 0.07nM
KSPki: 0.1nM
KSP(SKOV3cells)IC50: 0.2nM
KSP(MV522cells)IC50: 1.7nM
KSP(P388cells)IC50: 14.4nM
In vitro (25°C) DMSO 111 mg/mL (200.53 mM)
Water 22 mg/mL (39.74 mM)
Ethanol 111 mg/mL (200.53 mM)
In vivo Saline pH5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.07 mL 90.33 mL 180.67 mL
0.5 mM 3.61 mL 18.07 mL 36.13 mL
1 mM 1.81 mL 9.03 mL 18.07 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10828
Actions Inhibitor
M. Wt 553.5
Formula C31H33N2O3.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 940929-33-9
Synonyms SB-743921, SB743921
SMILES CC1=CC=C(C=C1)C(=O)N(CCCN)[[email protected]@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl

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