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SCH-527123 (Navarixin)

CXCR1/CXCR2 antagonist

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Catalog No. A11555
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Availability: Out of stock

Product Name Catalog No. Price
SCH-527123 5mg A11555-5
SCH-527123 10mg A11555-10
SCH-527123 25mg A11555-25
SCH-527123 50mg A11555-50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SCH527123 is a potent and selective antagonist of the human CXCR1 and CXCR2 receptors with IC50 of 42 nM and 3 nM, respectively.

SCH-527123 (Navarixin)

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Publications citing Adooq Products
SCH-527123 (Navarixin) Citations (2)
  • Fu S, .et al. Inhibition of interleukin 8/C-X-C chemokine receptor 1,/2 signaling reduces malignant features in human pancreatic cancer cells, Int J Oncol, 2018, Jul;53(1):349-357 PMID: 29749433
  • Fu S, .et al. Blocking Interleukin-6 and Interleukin-8 Signaling Inhibits Cell Viability, Colony-forming Activity, and Cell Migration in Human Triple-negative Breast Cancer and Pancreatic Cancer Cells, Anticancer Res, 2018, Nov;38(11):6271-6279 PMID: 30396947

Chemical Information

Catalog Num A11555
Actions Antagonist
M. Wt 397.42
Formula C21H23N3O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 473727-83-2
Synonyms SCH 527123, SCH527123
SMILES CC[[email protected]](C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C

Biological Activity

SCH527123 is a potent and selective antagonist of the human CXCR1 and CXCR2 receptors with IC50 of 42 nM and 3 nM, respectively.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.16 mL 125.81 mL 251.62mL
0.5 mM 5.03 mL 25.16 mL 50.32 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL

*The above data is based on the productmolecular weight 397.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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