SCH-527123 (Navarixin)

Catalog No.: A11555
CXCR1/CXCR2 antagonist
SCH527123 is a potent and selective antagonist of the human CXCR1 and CXCR2 receptors with IC50 of 42 nM and 3 nM, respectively.
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SCH-527123 5mg
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SCH-527123 10mg
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SCH-527123 25mg
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SCH-527123 50mg
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Adooq Products cited in reputable paper
Adooq's SCH-527123 (Navarixin) has been cited by 3 publications
  • Ruijie Zhang, .et al. , Int J Oncol, 2022, May;60(5):50 PMID: 35315502
  • Fu S, .et al. , Int J Oncol, 2018, Jul;53(1):349-357 PMID: 29749433
  • Fu S, .et al. , Anticancer Res, 2018, Nov;38(11):6271-6279 PMID: 30396947
  • Biological Activity
    Discription SCH527123 is a potent and selective antagonist of the human CXCR1 and CXCR2 receptors with IC50 of 42 nM and 3 nM, respectively.
    Target Value
    Product Information
    Catalog Num A11555
    Formula C21H23N3O5
    Molecular Weight 397.42
    CAS Number 473727-83-2
    SMILES CC[C@H](C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C
    Synonyms SCH 527123, SCH527123

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro DMSO 71 mg/mL (178.65 mM)
    Water Insoluble
    Ethanol 71 mg/mL (178.65 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 25.16 mL 125.81 mL 251.62 mL
    0.5 mM 5.03 mL 25.16 mL 50.32 mL
    1 mM 2.52 mL 12.58 mL 25.16 mL
    5 mM 0.5 mL 2.52 mL 5.03 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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