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HCV NS3/4A protease inhibitor

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Catalog No. A11580

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Simeprevir 5mg A11580-5
Simeprevir 10mg A11580-10
Simeprevir 50mg A11580-50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Simeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).


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Chemical Information

Catalog Num A11580
Actions Inhibitor
M. Wt 749.96
Formula C38H47N5O7S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 923604-59-5
Synonyms TMC435, TMC435350, TMC-435350
SMILES COC1=CC=C(C(O[[email protected]]2CC(C(N(C)CCCC/C=C\[[email protected]]3C[[email protected]@]3(C(NS(=O)(C4CC4)=O)=O)NC5=O)=O)[[email protected]]5C2)=CC(C6=NC(C(C)C)=CS6)=N7)C7=C1C

Biological Activity

Simeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.33 mL 66.67 mL 133.34mL
0.5 mM 2.67 mL 13.33 mL 26.67 mL
1 mM 1.33 mL 6.67 mL 13.33 mL
5 mM 0.27 mL 1.33 mL 2.67 mL

*The above data is based on the productmolecular weight 749.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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