Simeprevir

Catalog No.: A11580

HCV NS3/4A protease inhibitor

Simeprevir Chemical Structure

CAS NO. 923604-59-5

Simeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$210.00
50 mg
$850.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Simeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.33 mL 66.67 mL 133.34 mL
0.5 mM 2.67 mL 13.33 mL 26.67 mL
1 mM 1.33 mL 6.67 mL 13.33 mL
5 mM 0.27 mL 1.33 mL 2.67 mL

*The above data is based on the productmolecular weight 749.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11580
Actions Inhibitor
M. Wt 749.96
Formula C38H47N5O7S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 923604-59-5
Synonyms TMC435, TMC435350, TMC-435350
SMILES COC1=CC=C(C(O[[email protected]]2CC(C(N(C)CCCC/C=C\[[email protected]]3C[[email protected]@]3(C(NS(=O)(C4CC4)=O)=O)NC5=O)=O)[[email protected]]5C2)=CC(C6=NC(C(C)C)=CS6)=N7)C7=C1C

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