Sirtuins

Catalog No.Inhibitor Name SIRT1SIRT2SIRT3SirtuinOther
A10377Selisistat (EX 527)
****
A12226Sirtinol
*
**
A15902SirReal2
****
A14221Splitomicin
**
A14225AGK2
***
A12305Tenovin-6
***
*
p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. SirReal2

    Catalog No. A15902
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    Selective SIRT2 inhibitor
    SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. Learn More
  2. AK-7

    Catalog No. A12904
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    SIRT2 inhibitor
    AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). Learn More
  3. AGK2

    Catalog No. A14225
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    SIRT2 inhibitor
    AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM. Learn More
  4. Sirtinol

    Catalog No. A12226
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    sirtuin inhibitor
    Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. Learn More
  5. AK-1

    Catalog No. A14370
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    SIRT2 inhibitor
    AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3. Learn More

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