SNX-2112

Catalog No.: A11189

Hsp90 inhibitor

SNX-2112

SNX-2112 Chemical Structure

CAS NO. 908112-43-6

SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$220.00
50 mg
$550.00
100 mg
$920.00
10mM * 1mL in DMSO
$198.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Biological Activity

SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent

Targets
HSP90α HSP90β
30 nM(Ka)30 nM(Ka)
In vitro (25°C) DMSO 93 mg/mL (200.22 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL (2.15 mM)
In vivo 0.5% CMC/0.25% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.53 mL 107.65 mL 215.29 mL
0.5 mM 4.31 mL 21.53 mL 43.06 mL
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL

*The above data is based on the productmolecular weight 464.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11189
Actions Inhibitor
M. Wt 464.48
Formula C23H27F3N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 908112-43-6
Synonyms SNX2112, PF 04928473
SMILES CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C

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