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$0.00 Biological Activity
SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent
Targets
| HSP90α | HSP90β | |||
| 30 nM(Ka) | 30 nM(Ka) |
| In vitro (25°C) | DMSO | 93 mg/mL (200.22 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 1 mg/mL (2.15 mM) | ||
| In vivo | 0.5% CMC/0.25% Tween 80 | 30 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.53 mL | 107.65 mL | 215.29 mL |
| 0.5 mM | 4.31 mL | 21.53 mL | 43.06 mL |
| 1 mM | 2.15 mL | 10.76 mL | 21.53 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.31 mL |
*The above data is based on the productmolecular weight 464.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A11189 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 464.48 |
| Formula | C23H27F3N4O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 908112-43-6 |
| Synonyms | SNX2112, PF 04928473 |
| SMILES | CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C |
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