SNX-2112

Catalog No.: A11189
Hsp90 inhibitor

SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent

Grouped product items
Product Name Price Stock Qty
SNX-2112 5mg
$150.00
In stock
SNX-2112 10mg
$220.00
In stock
SNX-2112 50mg
$550.00
In stock
SNX-2112 100mg
$920.00
In stock
SNX-2112 10mM * 1mL in DMSO
$198.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's SNX-2112 has been cited by 2 publications
  • Michael Heider, .et al. , Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
  • Hiroki Murano, .et al. , Plant Biotechnol Rep, 2017, 11:107-113
  • Biological Activity
    Discription

    SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent

    Targets
    Target Value
    Product Information
    Catalog Num A11189
    Formula C23H27F3N4O3
    Molecular Weight 464.48
    CAS Number 908112-43-6
    SMILES CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C
    Synonyms SNX2112, PF 04928473
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 90 mg/mL (193.76 mM)
    Water Insoluble
    Ethanol 1 mg/mL (2.15 mM)
    In vivo 0.5% CMC+0.25% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.53 mL 107.65 mL 215.29 mL
    0.5 mM 4.31 mL 21.53 mL 43.06 mL
    1 mM 2.15 mL 10.76 mL 21.53 mL
    5 mM 0.43 mL 2.15 mL 4.31 mL
    Useful Calculator

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