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STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM).
Targets
| In vitro (25°C) | DMSO | 53 mg/mL (198.24 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 3 mg/mL (11.22 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 7 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.4 mL | 186.99 mL | 373.97 mL |
| 0.5 mM | 7.48 mL | 37.4 mL | 74.79 mL |
| 1 mM | 3.74 mL | 18.7 mL | 37.4 mL |
| 5 mM | 0.75 mL | 3.74 mL | 7.48 mL |
*The above data is based on the productmolecular weight 267.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A10866 |
|---|---|
| Actions | Inducer |
| M. Wt | 267.4 |
| Formula | C15H13N3S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 315702-99-9 |
| Synonyms | STF62247 |
| SMILES | CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3 |
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Contact information
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