T0070907

Catalog No.: A11588

PPAR-γ antagonist

T0070907 Chemical Structure

CAS NO. 313516-66-4

T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$60.00
50 mg
$160.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.
Targets
PPARγ (Cell-free assay) PPARα (Cell-free assay) PPARδ (Cell-free assay)
1 nM0.85 μM1.8 μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.02 mL 180.08 mL 360.15 mL
0.5 mM 7.2 mL 36.02 mL 72.03 mL
1 mM 3.6 mL 18.01 mL 36.02 mL
5 mM 0.72 mL 3.6 mL 7.2 mL

*The above data is based on the productmolecular weight 277.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11588
Actions Antagonist
M. Wt 277.66
Formula C12H8ClN3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 313516-66-4
Synonyms T 0070907
SMILES ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=CC=NC=C2)=O

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