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Products tagged with 'Bcl-2'

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  1. A-1155463

    Catalog No. A16112
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    BCL-XL inhibitor
    A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM) Learn More
  2. A-1331852

    Catalog No. A16190
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    BCL-XL inhibitor
    A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML. Learn More
  3. ABT-199 (Venetoclax)

    Catalog No. A12500
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    Bcl-2 inhibitor
    ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2. Learn More
  4. ABT-263 (Navitoclax)

    Catalog No. A10022
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    Bcl-2 inhibitor
    ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w).ABT-263 maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.
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  5. Acetate gossypol

    Catalog No. A14795
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    Bcl-2 Inhibitor
    Acetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic. Learn More
  6. AT-101

    Catalog No. A15004
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    Bcl-2 Inhibitor
    AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM. Learn More
  7. AT101 acetic acid

    Catalog No. A13578
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    pan Bcl-2 inhibitor
    AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID Learn More
  8. Bcl-2 Inhibitor

    Catalog No. A13580
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    Bcl-2 Inhibitor
    Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively). Learn More
  9. BDA-366

    Catalog No. A15821
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    Bcl-2 antagonist
    BDA-366 selectively inhibits BCL2, converting it to a cell death inducer. Learn More
  10. BM-1074

    Catalog No. A12743
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    Bcl-2/Bcl-xL inhibitor
    BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM. Learn More
  11. Gambogic acid

    Catalog No. A11988
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    Bcl-2 inhibitor
    Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively. Learn More
  12. HA14-1

    Catalog No. A11448
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    Bcl-2 inhibitor
    HA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2. Learn More
  13. Obatoclax mesylate (GX15-070)

    Catalog No. A10665
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    Bcl-2 Inhibitor
    Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). Learn More
  14. Sabutoclax

    Catalog No. A12823
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    Bcl-2 inhibitor
    Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. Learn More
  15. TW-37

    Catalog No. A10955
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    Bcl-2 inhibitor
    TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1. Learn More

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