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Products tagged with 'ATR'

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  1. AZ-20

    Catalog No. A13205
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    ATR kinase inhibitor
    AZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM. Learn More
  2. AZD6738

    Catalog No. A15794
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    ATR inhibitor
    AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells. Learn More
  3. CGK 733

    Catalog No. A13191
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    ATM/ATR inhibitor
    CGK733 is a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Learn More
  4. ETP-46464

    Catalog No. A13328
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    ATR inhibitor
    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM. Learn More
  5. NU-7441 (KU-57788)

    Catalog No. A11098
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    DNA-PK inhibitor
    NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively. Learn More
  6. NU6027

    Catalog No. A14136
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    ATR/CDK inhibitor
    NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. Learn More
  7. NU7026

    Catalog No. A12752
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    DNA-PK inhibitor
    NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Learn More
  8. Schisandrin B

    Catalog No. A11991
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    Schisandrin B is the most abundant dibenzocyclooctadiene isolated from the fruit of Schisandra chinensis (Turcz) Baillon or Wu-Wei-Zi (transliterally meaning "the fruit of five tastes" in Chinese), which is a commonly used tonic herb in Chinese medicine, particularly for the treatment of liver ailments. Learn More
  9. Torin 2

    Catalog No. A11586
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    mTOR inhibitor
    Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Learn More
  10. VE-821

    Catalog No. A11605
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    ATM/ATR inhibitor
    VE-821 is a potent and selective inhibitor of protein kinase ATR. Learn More
  11. VE-822

    Catalog No. A13289
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    ATR inhibitor
    VE-822 is an potent ATR inhibitor. Learn More
  12. Wortmannin

    Catalog No. A11161
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    PI3K inhibitor

    Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

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