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Products tagged with 'Bcl-2'
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A-1155463
Catalog No. A16112 BCL-XL inhibitorA-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM) Learn More -
A-1331852
Catalog No. A16190 BCL-XL inhibitorA-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML. Learn More -
ABT-199 (Venetoclax)
Catalog No. A12500 Bcl-2 inhibitorABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2. Learn More -
ABT-263 (Navitoclax)
Catalog No. A10022 Bcl-2 inhibitorABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). it maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.Learn More -
Acetate gossypol
Catalog No. A14795 Bcl-2 InhibitorAcetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic. Learn More -
AT-101
Catalog No. A15004 Bcl-2 InhibitorAT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM. Learn More -
AT101 acetic acid
Catalog No. A13578 pan Bcl-2 inhibitorAT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID Learn More -
Bcl-2 Inhibitor
Catalog No. A13580 Bcl-2 InhibitorBcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively). Learn More -
BDA-366
Catalog No. A15821 Bcl-2 antagonistBDA-366 selectively inhibits BCL2, converting it to a cell death inducer. Learn More -
BM-1074
Catalog No. A12743 Bcl-2/Bcl-xL inhibitorBM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM. Learn More -
Gambogic acid
Catalog No. A11988 Bcl-2 inhibitorGambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively. Learn More -
HA14-1
Catalog No. A11448 Bcl-2 inhibitorHA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2. Learn More -
Obatoclax mesylate (GX15-070)
Catalog No. A10665 Bcl-2 InhibitorBcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). Learn More -
Sabutoclax
Catalog No. A12823 Bcl-2 inhibitorSabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. Learn More -
TW-37
Catalog No. A10955 Bcl-2 inhibitorTW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1. Learn More
15 Item(s)
per page