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Products tagged with 'CDK2'

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  1. AZD5438

    Catalog No. A11105
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    CDK inhibitor
    AZD5438 is a potent inhibitor of cyclin-dependent kinase (CDK) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). Learn More
  2. BMS-265246

    Catalog No. A11154
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    CDK inhibitor
    BMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D. Learn More
  3. Dinaciclib (SCH 727965)

    Catalog No. A11129
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    CDK Inhibitor
    Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively. Learn More
  4. Flavopiridol (Alvocidib)

    Catalog No. A10390
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    CDK inhibitor
    Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. Learn More
  5. Flavopiridol HCl

    Catalog No. A11045
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    CDK inhibitor
    Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells. Learn More
  6. GW 441756

    Catalog No. A16238
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    TrkA inhibitor
    GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2. Learn More
  7. K03861

    Catalog No. A15889
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    CDK inhibitor
    K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. Learn More
  8. NU6027

    Catalog No. A14136
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    ATR/CDK inhibitor
    NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. Learn More
  9. Purvalanol A

    Catalog No. A15517
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    CDK inhibitor
    Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn More
  10. SCH 900776 (MK-8776)

    Catalog No. A11167
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    Chk1 inhibitor

    SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

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