Subscribe to Feed

Products tagged with 'DNA synthesis'

11 Item(s)

per page

Set Descending Direction
  1. Bendamustine HCl (SDX-105)

    Catalog No. A10124
    Quick View

    Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe.

    Learn More
  2. Carboplatin

    Catalog No. A10182
    Quick View

    Carboplatin is a chemotherapy drug used against some forms of cancer (mainly ovarian carcinoma, lung, head and neck cancers). Cisplatin and carboplatin, as well as oxaliplatin, interact with DNA, akin to the mechanism of alkylating agents.

    Learn More
  3. Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

    Catalog No. A10194
    Quick View
    Topoisomerase inhibitor

    Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

    Learn More
  4. Cisplatin

    Catalog No. A10221
    Quick View
    Cisplatin was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death). Learn More
  5. Cytarabine

    Catalog No. A10265
    Quick View
    Cytarabine inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Learn More
  6. Daptomycin

    Catalog No. A10289
    Quick View
    DNA/RNA Synthesis inhibitor
    Daptomycin is a lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Learn More
  7. Gemcitabine HCl (Gemzar)

    Catalog No. A10423
    Quick View
    DNA/RNA Synthesis inhibitor
    Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth. Learn More
  8. Mitomycin C

    Catalog No. A11491
    Quick View
    DNA synthesis inhibitor
    Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells. Learn More
  9. Nelarabine (Arranon)

    Catalog No. A10632
    Quick View
    Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Learn More
  10. Oxaliplatin (Eloxatin)

    Catalog No. A10346
    Quick View
    DNA/RNA Synthesis inhibitor
    Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. In vivo studies showed that Oxaliplatin has anti-tumor activity against colon carcinoma through its (non-targeted) cytotoxic effects. Learn More
  11. Trifluridine

    Catalog No. A10948
    Quick View
    Trifluridine is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into GlaxoSmithKline. Learn More

11 Item(s)

per page

Set Descending Direction
Rewards