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Products tagged with 'FLT3'

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  1. AC220 (Quizartinib)

    Catalog No. A10027
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    FLT3 inhibitor
    AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. Learn More
  2. AMG-925

    Catalog No. A14025
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    Dual FLT3/CDK4 inhibitor
    AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. Learn More
  3. AZD 2932

    Catalog No. A14156
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    mutil-targeted protein tyrosine kinase inhibitor
    AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively. Learn More
  4. Go 6976

    Catalog No. A12419
    PKC inhibitor
    Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3. Learn More
  5. MP470 (MP-470, Amuvatinib)

    Catalog No. A10610
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    RTK inhibitor
    MP470 is a c-Kit/PDGFR tyrosine kinase inhibitor. Learn More
  6. Pexidartinib (PLX3397)

    Catalog No. A15520
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    CSF1/Kit/FLT3 inhibitor
    Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Learn More
  7. R406 besylate

    Catalog No. A10769
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    Syk Inhibitor
    R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. Learn More
  8. SGI-1776 (free base)

    Catalog No. A10838
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    PIM1 Inhibitor
    SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1. Learn More
  9. TCS 359

    Catalog No. A12427
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    FLT3 inhibitor
    TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Learn More
  10. TG-101348 (Fedratinib, SAR302503)

    Catalog No. A11082
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    JAK2/FLT3 inhibitor
    TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity. Learn More
  11. TG101209

    Catalog No. A11180
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    JAK2 inhibitor

    TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

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  12. VX-680 (MK-0457, Tozasertib)

    Catalog No. A10981
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    Aurora Kinase inhibitor
    VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases. Learn More

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