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Products tagged with 'JAK2'

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  1. AG-490

    Catalog No. A10047
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    EGFR inhibitor
    AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src. Learn More
  2. AZ-960

    Catalog No. A10104
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    JAK2inhibitor
    AZ-960 is a potent, selective and ATP competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45 nM in vitro and induces growth arrest and apoptosis in adult T-cell leukemia (ATL) cell. Learn More
  3. AZD1480

    Catalog No. A10110
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    JAK Inhibitor
    AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. Learn More
  4. BMS-911543

    Catalog No. A11241
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    JAK inhibitor
    BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. Learn More
  5. CEP33779

    Catalog No. A12808
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    JAK2 Inhibitor
    CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM. Learn More
  6. Cyt387 (Momelotinib)

    Catalog No. A10263
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    JAK inhibitor
    CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. Learn More
  7. Decernotinib

    Catalog No. A14012
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    JAK3 inhibitor
    Decernotinib is an oral, selective Janus kinase 3 (JAK3) inhibitor being developed by Vertex. Learn More
  8. Filgotinib

    Catalog No. A14232
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    JAK inhibitor
    Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Learn More
  9. FLLL32

    Catalog No. A15911
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    JAK2 inhibitor
    FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 uM. Learn More
  10. Go 6976

    Catalog No. A12419
    PKC inhibitor
    Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3. Learn More
  11. INCB018424 (Ruxolitinib)

    Catalog No. A11041
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    JAK1/2 Inhibitor
    INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; Learn More
  12. PP2

    Catalog No. A12723
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    Src Inhibitor
    PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM). Learn More
  13. TG-101348 (Fedratinib, SAR302503)

    Catalog No. A11082
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    JAK2/FLT3 inhibitor
    TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity. Learn More
  14. TG101209

    Catalog No. A11180
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    JAK2 inhibitor

    TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

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  15. WP1066

    Catalog No. A11795
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    JAK Inhibitor
    WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation. Learn More

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