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Products tagged with 'MEK1'

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  1. AS703026 (Pimasertib)

    Catalog No. A10089
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    MEK1/2 inhibitor
    AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation. Learn More
  2. AZD6244 (Selumetinib)

    Catalog No. A10257
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    MEK inhibitor
    AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm. Learn More
  3. AZD8330

    Catalog No. A10115
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    MEK Inhibitor
    AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. Learn More
  4. BI-847325

    Catalog No. A15762
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    MEK/Aurora Inhibitor
    BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. Learn More
  5. GDC-0623

    Catalog No. A12974
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    MEK1 inhibitor
    GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. Learn More
  6. GDC-0973 (Cobimetinib)

    Catalog No. A11441
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    MEK1 inhibitor
    Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Learn More
  7. GSK1120212 (JTP-74057, Trametinib)

    Catalog No. A11029
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    MEK Inhibitor
    GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases. Learn More
  8. PD184352 (CI-1040)

    Catalog No. A10212
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    MEK1/2 inhibitor
    PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2. Learn More
  9. PD318088

    Catalog No. A10704
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    MEK Inhibitor
    PD318088 is an inhibitor of MEK1 AND MEK2. Learn More
  10. PD98059

    Catalog No. A10705
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    MEK Inhibitor
    PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Learn More
  11. Refametinib

    Catalog No. A11264
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    MEK inhibitor
    Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. Learn More
  12. RO5126766 (CH5126766)

    Catalog No. A14019
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    Raf/MEK dual inhibitor
    RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Learn More
  13. SCH772984

    Catalog No. A12824
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    ERK Inhibitor
    SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. Learn More
  14. TAK-733

    Catalog No. A11040
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    MEK Inhibitor
    TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Learn More

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