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Products tagged with 'mTOR'

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  1. AZ-20

    Catalog No. A13205
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    ATR kinase inhibitor
    AZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM. Learn More
  2. AZD2014 (Vistusertib)

    Catalog No. A11303
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  3. CC-223

    Catalog No. A13078
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    mTOR Inhibitor
    CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM). Learn More
  4. Chrysophanic acid (Chrysophanol)

    Catalog No. A10210
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    EGFR inhibitor
    Chrysophanic acid (Chrysophanol) blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Learn More
  5. Deforolimus (Ridaforolimus)

    Catalog No. A10295
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    mTOR Inhibitor

    Deforolimus (Ridaforolimus) is an investigational targeted and small-molecule inhibitor of the protein mTOR. Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and angiogenesis.

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  6. ETP-46464

    Catalog No. A13328
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    ATR inhibitor
    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM. Learn More
  7. Everolimus (RAD001)

    Catalog No. A10374
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    mTOR inhibitor
    Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor. Learn More
  8. GDC-0349

    Catalog No. A11443
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    mTOR inhibitor
    GDC-0349 is under evaluating the Safety and Tolerability in Patients with locally advanced or metastatic solid tumors or non hodgkin's lymphoma. Learn More
  9. GDC-0980 (Apitolisib, RG7422)

    Catalog No. A11023
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    mTOR/PI3K Inhibitor
    GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively. Learn More
  10. GSK1059615

    Catalog No. A10438
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    mTOR/PI3K Inhibitor
    GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM). Learn More
  11. LY3023414

    Catalog No. A16126
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    PI3K/mTOR Dual Inhibitor
    LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242). Learn More
  12. MHY1485

    Catalog No. A15508
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    mTOR inhibitor
    MHY1485 is a mTOR activator; inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes. Learn More
  13. NU-7441 (KU-57788)

    Catalog No. A11098
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    DNA-PK inhibitor
    NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively. Learn More
  14. NVP-BGT226

    Catalog No. A11162
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    PI3K inhibitor

    NVP-BGT226, novel phosphoinositide 3-kinase/mTOR dual inhibitor, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo.

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  15. PKI-402

    Catalog No. A11089
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    PI3K inhibitor
    PKI-402 is a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor. Learn More
  16. PKI-587 ( Gedatolisib )

    Catalog No. A11079
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    PI3K/mTOR inhibitor
    PKI-587 is a highly potent PI3K/mTOR kinase inhibitor that inhibits PI3K-α,β,γ, δ isoforms and mTOR with IC50 of 0.4, 6.0, 5.4, 6.0 and 1.6 nM respectively. Learn More
  17. Rapamycin (Sirolimus)

    Catalog No. A10782
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    mTOR Inhibitors
    Rapamycin (Sirolimus) prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2). Learn More
  18. Temsirolimus (Torisel)

    Catalog No. A10906
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    mTOR inhibitor
    Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. Learn More
  19. Torin 2

    Catalog No. A11586
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    mTOR inhibitor
    Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Learn More
  20. VS-5584

    Catalog No. A12480
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    PI3K/mTOR inhibitor
    VS-5584 is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Learn More
  21. WYE-125132 (WYE-132)

    Catalog No. A11038
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    mTOR Inhibitor
    WYE-125132 is an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 (IC50 = 0.19 nM; >5,000-fold selective versus PI3Ks). Learn More

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