Subscribe to Feed

Products tagged with 'p53'

26 Item(s)

per page

Set Descending Direction
  1. AMG232

    Catalog No. A14394
    MDM2 inhibitor
    AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM). Learn More
  2. Idasanutlin (RG7388)

    Catalog No. A14211
    Quick View
    MDM2/p53 Inhibitor
    Idasanutlin is a potent and selective p53-MDM2 inhibitor. Learn More
  3. JNJ 26854165

    Catalog No. A10491
    Quick View
    p53 activator
    JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias. Learn More
  4. MDM2 Inhibitor

    Catalog No. A13582
    Quick View
    MDM2 inhibitor
    MDM2 Inhibitor is a cell-permeable boranyl-chalcone exhibiting strong binding to MDM2 and irreversibly disrupts the MDM2/p53 protein complex. Learn More
  5. MI-773

    Catalog No. A15440
    Quick View
    MDM2 inhibitor
    MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM. Learn More
  6. MIRA-1

    Catalog No. A15348
    Quick View
    p53 inducer
    MIRA-1 restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA. Learn More
  7. NSC 146109 hydrochloride

    Catalog No. A15349
    Quick View
    p53 activator
    NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Learn More
  8. NSC 319726

    Catalog No. A12930
    Quick View
    p53R175 activator
    NSC 319726 is a potent and selective activator of mutant p53R175 Learn More
  9. NSC-207895 (XI-006)

    Catalog No. A11179
    Quick View
    MDMX Inhibitor

    NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

    Learn More
  10. NSC59984

    Catalog No. A13413
    Quick View
    P53 Activator
    NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells. Learn More
  11. Nutlin 3a

    Catalog No. A11501
    Quick View
    MDM2 inhibitor
    Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53. Learn More
  12. Nutlin 3b

    Catalog No. A11502
    Quick View
    MDM2 inhibitor
    Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. Learn More
  13. p53 and MDM2 proteins-interaction-inhibitor chiral

    Catalog No. A15201
    Quick View
    p53-MDM2 interaction inhibitor
    p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins. Learn More
  14. p53 and MDM2 proteins-interaction-inhibitor racemic

    Catalog No. A15202
    Quick View
    p53-MDM2 interaction inhibitor
    p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins. Learn More
  15. PhiKan 083

    Catalog No. A15350
    Quick View
    p53 stabilizer
    PhiKan 083, p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Learn More
  16. Pifithrin-alpha

    Catalog No. A12451
    Quick View
    p53 inhibitor
    Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Learn More
  17. Pifithrin-beta

    Catalog No. A12450
    Quick View
    p53 Inhibitor
    Pifithrin-beta is a small molecule inhibitor of p53. Learn More
  18. Pifithrin-u

    Catalog No. A12449
    Quick View
    p53 inhibitor
    inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Learn More
  19. PRIMA-1

    Catalog No. A13581
    Quick View
    p53 reactivator
    PRIMA-1 is a small molecule identified for its p53 reactivating effect. Learn More
  20. RETRA hydrochloride

    Catalog No. A15351
    Quick View
    mutant p53 Reactivator
    RETRA hydrochloride is an antitumor agent which inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and iin vivo. Learn More
  21. RITA (NSC 652287)

    Catalog No. A11931
    Quick View
    p53 activator
    RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis. Learn More
  22. Tenovin-1

    Catalog No. A11943
    Quick View
    p53 activator
    Tenovin-1 is a small molecule activator of p53 transcriptional activity that protects against MDM2-mediated p53 degradation. Learn More
  23. Tenovin-3

    Catalog No. A13727
    Quick View
    p53 activator
    Tenovin-3 is a sirtuin inhibitor. Learn More
  24. Tenovin-6

    Catalog No. A12305
    Quick View
    p53 activator
    Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively. Learn More
  25. WR 1065

    Catalog No. A15353
    Quick View
    P53/p21waf-1/MDM2 activator
    WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure. Learn More
  26. YH239-EE

    Catalog No. A14118
    Quick View
    Mdm2 inhibitor
    YH239-EE is a potent p53-MDM2 antagonist and an apoptosis inducer. Learn More

26 Item(s)

per page

Set Descending Direction
Rewards