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Products tagged with 'PARP1'

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  1. A-966492

    Catalog No. A10019
    PARP1 inhibitor
    A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. Learn More
  2. AG14361

    Catalog No. A10046
    PARP inhibitor
    AG14361 is a potent PARP inhibitor, enhanced Temozolomide (TMZ) cytotoxicity in MMR(mismatch repair)-proficient / deficient cells. Learn More
  3. BSI-201 (Iniparib)

    Catalog No. A10164
    PARP inhibitor
    BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier. Learn More
  4. ME0328

    Catalog No. A14309
    PARP3 inhibitor
    ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. Learn More
  5. MK-4827 (Niraparib)

    Catalog No. A11026
    PARP inhibitor
    MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor. Learn More
  6. Olaparib (AZD2281)

    Catalog No. A10111
    PARP inhibitor
    Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. Learn More
  7. UPF 1069

    Catalog No. A12750
    PARP2 inhibitor
    UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively). Learn More

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