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Products tagged with 'PARP1'

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  1. A-966492

    Catalog No. A10019
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    PARP1 inhibitor
    A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. Learn More
  2. AG14361

    Catalog No. A10046
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    PARP inhibitor
    AG14361 is a potent PARP inhibitor, enhanced Temozolomide (TMZ) cytotoxicity in MMR(mismatch repair)-proficient / deficient cells. Learn More
  3. BSI-201 (Iniparib)

    Catalog No. A10164
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    PARP inhibitor
    BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier. Learn More
  4. ME0328

    Catalog No. A14309
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    PARP3 inhibitor
    ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. Learn More
  5. MK-4827 (Niraparib)

    Catalog No. A11026
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    PARP inhibitor
    MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor. Learn More
  6. Olaparib (AZD2281)

    Catalog No. A10111
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    PARP inhibitor
    Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. Learn More
  7. UPF 1069

    Catalog No. A12750
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    PARP2 inhibitor
    UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively). Learn More

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