Subscribe to Feed

Products tagged with 'PI3Kα'

22 Item(s)

per page

Set Descending Direction
  1. AMG319

    Catalog No. A15901
    Quick View
    PI3Kδ inhibitor
    AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2. Learn More
  2. AS-252424

    Catalog No. A11099
    Quick View
    PI3K inhibitor
    AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively. Learn More
  3. AS-605240

    Catalog No. A10088
    Quick View
    PI3K Inhibitor
    AS-605240 is an orally active inhibitor of PI3-kinase γ that inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. Learn More
  4. AZD6482

    Catalog No. A10112
    Quick View
    PI3K inhibitor
    AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy. Learn More
  5. BAY 80-6946 (Copanlisib)

    Catalog No. A11766
    Quick View
    PI3K inhibitor
    BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Learn More
  6. BYL719 (Alpelisib)

    Catalog No. A11328
    Quick View
    PI3K Inhibitor
    BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Learn More
  7. CC-223

    Catalog No. A13078
    Quick View
    mTOR Inhibitor
    CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM). Learn More
  8. ETP-46464

    Catalog No. A13328
    Quick View
    ATR inhibitor
    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM. Learn More
  9. GDC-0084

    Catalog No. A16272
    Quick View
    PI3K inhibitor
    GDC-0084 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Learn More
  10. GDC-0349

    Catalog No. A11443
    Quick View
    mTOR inhibitor
    GDC-0349 is under evaluating the Safety and Tolerability in Patients with locally advanced or metastatic solid tumors or non hodgkin's lymphoma. Learn More
  11. GSK1059615

    Catalog No. A10438
    Quick View
    mTOR/PI3K Inhibitor
    GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM). Learn More
  12. HS-173

    Catalog No. A13021
    Quick View
    PI3K Inhibitor
    HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. Learn More
  13. KU 0060648

    Catalog No. A13224
    Quick View
    DNA-PK inhibitor
    KU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency. Learn More
  14. NVP-BGT226

    Catalog No. A11162
    Quick View
    PI3K inhibitor

    NVP-BGT226, novel phosphoinositide 3-kinase/mTOR dual inhibitor, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo.

    Learn More
  15. PIK-90

    Catalog No. A10730
    Quick View
    PI3K Inhibitor
    PIK-90 is a synthetic phosphoinositide 3-kinase (PI3K) inhibitor with IC50 values (nM) of 11, 350, 18, and 58 for p110 α, β, γ and δ isoforms, low mTOR activity. Learn More
  16. PKI-402

    Catalog No. A11089
    Quick View
    PI3K inhibitor
    PKI-402 is a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor. Learn More
  17. PKI-587 ( Gedatolisib )

    Catalog No. A11079
    Quick View
    PI3K/mTOR inhibitor
    PKI-587 is a highly potent PI3K/mTOR kinase inhibitor that inhibits PI3K-α,β,γ, δ isoforms and mTOR with IC50 of 0.4, 6.0, 5.4, 6.0 and 1.6 nM respectively. Learn More
  18. TG 100713

    Catalog No. A11956
    Quick View
    PI3K inhibitor
    TG 100713 is an inhibitor of PI3-kinase that inhibits endothelial cell proliferation. Learn More
  19. TG100-115

    Catalog No. A10922
    Quick View
    PI3K Inhibitor
    TG100-115 inhibits PI3K γ and -δ(IC50 values of 83 and 235 nM, respectively). Learn More
  20. VS-5584

    Catalog No. A12480
    Quick View
    PI3K/mTOR inhibitor
    VS-5584 is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Learn More
  21. XL-147 (Pilaralisib)

    Catalog No. A15283
    Quick View
    PI3K Inhibitor
    XL147 is a potent, orally bioavailable inhibitor of the class I PI3K family of lipid kinases. Learn More
  22. ZSTK474

    Catalog No. A11014
    Quick View
    PI3K inhibitor
    ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. Learn More

22 Item(s)

per page

Set Descending Direction
Rewards