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Products tagged with 'Topoisomerase II'

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  1. Adriamycin

    Catalog No. A10041
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    topoisomerase II inhibitor

    Adriamycin is an anthracycline antibiotic, it works by intercalating DNA, while most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas.

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  2. Amonafide (AS1413)

    Catalog No. A10071
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    Topoisomerase inhibitor

    Amonafide is a DNA intercalator and topoisomerase II inhibitor for the treatment of neoplastic diseases, one of Antitumor agent.

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  3. Ellagic acid

    Catalog No. A10344
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    Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption. Learn More
  4. Etoposide (VP-16)

    Catalog No. A10373
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    Topoisomerase II inhibitor
    Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell. Learn More
  5. Flumequine

    Catalog No. A11861
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    Topoisomerase II inhibitor
    Flumequine is a synthetic chemotherapeutic antibiotic which affecting mammalian chromosome and DNA unwinding at the level of gyrase/topoisomerases. Learn More
  6. Idarubicin HCl

    Catalog No. A10465
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    Topoisomerase inhibitor
    Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin. Learn More
  7. Marbofloxacin

    Catalog No. A10557
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    Topoisomerase inhibitor
    Marbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group and acts by inhibiting bacterial DNA replication. Learn More
  8. Mitoxantrone

    Catalog No. A10595
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    Mitoxantrone is a synthetic antineoplastic anthracenedione (IC50 = 0.42 mM). Learn More
  9. Mitoxantrone Hydrochloride

    Catalog No. A10596
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    Mitoxantrone Dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Learn More
  10. Moxifloxacin HCl

    Catalog No. A10609
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    Topoisomerase inhibitor
    Moxifloxacin is a quinolone/fluoroquinolone antibiotic. Learn More
  11. Ofloxacin (DL8280)

    Catalog No. A10666
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    Topoisomerase inhibitor
    Ofloxacin is a synthetic broad-spectrum antimicrobial agent. Learn More
  12. Pirarubicin

    Catalog No. A10735
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    Topoisomerase II inhibitor
    Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with Topo II (topoisomerase II) and supressing DNA replication Learn More
  13. Teniposide

    Catalog No. A10907
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    Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity. Learn More
  14. Voreloxin Hydrochloride

    Catalog No. A15280
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    Topoisomerase inhibitor
    Voreloxin Hcl is a small molecule and a naphthyridine analogue with antineoplastic activity; inhibitor of Topo II. Learn More

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