TH287

Catalog No.: A15536

MTH1 inhibitor

TH287

TH287 Chemical Structure

CAS NO. 1609960-30-6

TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16,

Availability: In stock

Package Price Qty
10 mg
$90.00
25 mg
$250.00
50 mg
$480.00
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Biological Activity

TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16,
Targets
MTH1 (NUDT1)
0.8 nM
In vitro DMSO 48 mg/mL (178.35 mM)
Water Insoluble
Ethanol Warmed: 9 mg/mL (33.44 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.16 mL 185.78 mL 371.57 mL
0.5 mM 7.43 mL 37.16 mL 74.31 mL
1 mM 3.72 mL 18.58 mL 37.16 mL
5 mM 0.74 mL 3.72 mL 7.43 mL

*The above data is based on the productmolecular weight 269.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15536
Actions Inhibitor
CAS No. 1609960-30-6
Formula C11H10Cl2N4
M. Wt 269.13
Purity >98%
Synonyms TH-287, TH 287
SMILES CNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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