Tie-2

Catalog No.Inhibitor Name Tie-2Other
A10996Cabozantinib
***
VEGFR2/KDR,c-Met,Kit
A10587MGCD-265
****
Met,RON,VEGFR2
A10932Tie2 kinase inhibitor
**
A13456AMG-Tie2-1
****
A10895Pexmetinib (ARRY-614)
p38 MAPK
A14387Altiratinib (DCC2701)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. XL184 free base (Cabozantinib)

    Catalog No. A10996
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    VEGFR inhibitor
    XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More
  2. MGCD-265 (Glesatinib)

    Catalog No. A10587
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    c-Met inhibitor
    MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs, including the c-Met receptor (HGFR); the Tek/Tie-2 receptor; VEGFR types 1, 2, and 3; and MST1R. Learn More
  3. Tie2 kinase inhibitor

    Catalog No. A10932
    Tie2 kinase inhibitor
    Tie2 kinase inhibitor is a potent and selective Tie2 inhibitor with IC50 of 0.25 μM. Learn More
  4. AMG-Tie2-1

    Catalog No. A13456
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    Tie-2 inhibitor
    AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC50 <1 nM). Learn More
  5. Altiratinib (DCC2701)

    Catalog No. A14387
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    c-Met/VEGFR inhibitor
    Altiratinib is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Learn More
  6. Pexmetinib (ARRY-614)

    Catalog No. A10895
    p38 MAPK inhibitor
    Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase. Learn More
  7. CE-245677

    Catalog No. A19377
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    Tie2 and TrkA/B inhibitor
    CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. Learn More

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