TMS is a potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50= 6 nM). 5N/A- and 520-fold selective over P450 1A1 and 1A2 respectively.
TMS is a potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50= 6 nM). 5N/A- and 520-fold selective over P450 1A1 and 1A2 respectively.
Targets
Target
Value
Product Information
Catalog Num
A11977
Formula
C18H20O4
Molecular Weight
300.35
CAS Number
24144-92-1
SMILES
COC1=CC(=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC)OC
Synonyms
E)-2,3',4,5'-tetramethoxystilbene
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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