Toll-like Receptors

Imiquimod (Aldara) is a a heterocyclic imidazoquinoline amide that acts as an immune response modifier.

PF-4878691 (3M-852A) is a potent, orally active, and selective Toll-like receptor 7 (TLR7) agonist modelled to dissociate its antiviral and inflammatory activities.

VTX-2337 is a small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating and antineoplastic activities.

GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.

Isatoribine is a novel guanosine analogue showing immunostimulatory activity both in vivo and in vitro.

Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.

TLR7-agonist-1 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM.

Gardiquimod is a chemical compound which acts selectively at both mouse and human forms of toll-like receptor 7 (TLR7). It functions as an immune response modifier. CAS: 1159840-61-5 (TFA) 1020412-43-4 (free base)

TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC50 of 90 nM.

CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist that activates TLR3, TLR8, and TLR9.

LHC-165 is a TLR7 agonist. Has potential to treat solid tumors.

Telratolimod is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline.