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IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein.
CU-CPT9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM. CU-CPT9b shows high binding affinity towards TLR8 with a Kd of 21 nM.
CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67 nM.
CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity.
TLR5/flagellin complex antagonist
TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 μM.
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