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- Yevgen Yudin,et al. The G protein-biased PZM21 and TRV130 act as partial agonists of 米-opioid receptors signaling to ion channel targets, bioRxiv, 2018, 2018
- Araldi D,et al. Mu-Opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat, Neuroscience, 2018, Dec 1; 394: 60-71 30342200
|Storage||at -20°C 3 years Powder|
|Synonyms||TRV 130, TRV-130|
|SMILES code||COC1=C(SC=C1)CNCC[[email protected]]2(CCOC3(C2)CCCC3)C4=CC=CC=N4|
|Chemical Name||(R)-N-((3-methoxythiophen-2-yl)methyl)-2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)ethanamine hydrochloride|
|TRV130 is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less ??-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine.|
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||23.64 mL||118.2 mL||236.4mL|
|0.5 mM||4.73 mL||23.64 mL||47.28 mL|
|1 mM||2.36 mL||11.82 mL||23.64 mL|
|5 mM||0.47 mL||2.36 mL||4.73 mL|
*The above data is based on the productmolecular weight 423.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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