TRV130 (Oliceridine)

Catalog No.: A14337

μ-opioid receptor agonist

TRV130 (Oliceridine)

TRV130 (Oliceridine) Chemical Structure

CAS NO. 1401028-24-7

TRV130 is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less ??-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine.

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Package Price Qty
5 mg
$90.00
10 mg
$150.00
25 mg
$300.00
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  • Lakshmi Vasudevan, .et al. Assessment of Structure-Activity Relationships and Biased Agonism at the Mu Opioid Receptor of Novel Synthetic Opioids Using a Novel, Stable Bio-Assay Platform, Biochem Pharmacol, 2020, Mar 14;177:113910 PMID: 32179045
  • Yudin Y, .et al. The G protein‐biased agents PZM21 and TRV130 are partial agonists of μ‐opioid receptor‐mediated signaling to ion channels, Br J Pharmacol, 2019, May 9 PMID: 31074038
  • Anna M. Gutridge, .et al. G protein‐biased kratom‐alkaloids and synthetic carfentanil‐amide opioids as potential treatments for alcohol use disorder, Br J Pharmaco, 2019, 08 November
  • Araldi D, .et al. Mu-Opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat, Neuroscience, 2018, Dec 1; 394: 60-71 PMID: 30342200
  • Yevgen Yudin, .et al. The G protein-biased PZM21 and TRV130 act as partial agonists of μ-opioid receptors signaling to ion channel targets, bioRxiv, 2018, 2018
  • Luma

Biological Activity

TRV130 is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less ??-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.64 mL 118.2 mL 236.4 mL
0.5 mM 4.73 mL 23.64 mL 47.28 mL
1 mM 2.36 mL 11.82 mL 23.64 mL
5 mM 0.47 mL 2.36 mL 4.73 mL

*The above data is based on the productmolecular weight 423.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14337
Actions Agonist
M. Wt 423.01
Formula C22H31ClN2O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1401028-24-7
Synonyms TRV 130, TRV-130
SMILES COC1=C(SC=C1)CNCC[[email protected]]2(CCOC3(C2)CCCC3)C4=CC=CC=N4

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