TW-37

Catalog No.: A10955
Bcl-2 inhibitor
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.
Grouped product items
Product Name Price Stock Qty
TW-37 10mg
$80.00
In stock
TW-37 25mg
$150.00
In stock
TW-37 50mg
$250.00
In stock
TW-37 100mg
$400.00
In stock
TW-37 10mM * 1mL in DMSO
$105.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.
Targets
Target Value
Product Information
Catalog Num A10955
Formula C33H35NO6S
Molecular Weight 573.7
CAS Number 877877-35-5
SMILES CC(C)C1=CC=CC=C1CC2=C(C(=C(C(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C)O)O)O
Synonyms TW37
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 110 mg/mL (191.73 mM)
Water Insoluble
Ethanol 4 mg/mL (6.97 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.43 mL 87.15 mL 174.31 mL
0.5 mM 3.49 mL 17.43 mL 34.86 mL
1 mM 1.74 mL 8.72 mL 17.43 mL
5 mM 0.35 mL 1.74 mL 3.49 mL
Useful Calculator

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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