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TW-37

Bcl-2 inhibitor

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Catalog No. A10955

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TW-37 10mg A10955-10
$80.00
TW-37 25mg A10955-25
$150.00
TW-37 50mg A10955-50
$250.00
TW-37 100mg A10955-100
$400.00
TW-37 10mM * 1mL in DMSO A10955-10mM-D
$105.00
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Quick Overview

TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.

TW-37

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Chemical Information

Catalog Num A10955
Actions Inhibitor
M. Wt 573.7
Formula C33H35NO6S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 877877-35-5
Synonyms TW37
SMILES CC(C)C1=CC=CC=C1CC2=C(C(=C(C(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C)O)O)O

Biological Activity

Description
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.
Targets
Mcl-1 (Cell-free assay) Bcl-2 (Cell-free assay) Bcl-xL (Cell-free assay)
0.26 μM(Ki)0.29 μM(Ki)1.11 μM(Ki)
Cell data
Cell LinesAssay DescriptionActivity (IC50 μM)Source
NB5Inhibition of human NB5 cell growth0.423358475Sanger
GP5dInhibition of human GP5d cell growth0.781758038Sanger
ES5Inhibition of human ES5 cell growth0.884301687Sanger
SK-MEL-30Inhibition of human SK-MEL-30 cell growth0.037974553Sanger
SK-MEL-5Inhibition of human SK-MEL-5 cell growth0.0692453Sanger
LK-2Inhibition of human LK-2 cell growth1.503431256Sanger
OVCAR-4Inhibition of human OVCAR-4 cell growth0.609531286Sanger
BeckerInhibition of human Becker cell growth0.242111479Sanger
SK-LU-1Inhibition of human SK-LU-1 cell growth0.711414527Sanger
KYSE-520 cell lineInhibition of human KYSE-520 cell growth4.138564547Sanger
NCI-H226Inhibition of human NCI-H226 cell growth2.459588354Sanger
SBC-5Inhibition of human SBC-5 cell growth0.147115101Sanger
MLMAInhibition of human MLMA cell growth0.185103158Sanger
KYSE-510Inhibition of human KYSE-510 cell growth0.22233545Sanger
NCI-N87Inhibition of human NCI-N87 cell growth2.196040574Sanger
UO-31Inhibition of human U031 cell growth0.183870789Sanger
COLO-829Inhibition of human COLO-829 cell growth0.700551778Sanger
AM-38Inhibition of human AM-38 cell growth0.840886152Sanger
ABC-1Inhibition of human ABC-1 cell growth0.315500188Sanger
23132-87Inhibition of human 23132-87 cell growth0.32420508Sanger
CAL-12TInhibition of human CAL-12T cell growth1.121476365Sanger
CAL-120Inhibition of human CAL-120 cell growth0.479194361Sanger
BB65-RCCInhibition of human BB65-RCC cell growth0.134543999Sanger
COLO-668Inhibition of human COLO-668 cell growth5.099783052Sanger
BT-20Inhibition of human BT-20 cell growth0.655908488Sanger
COLO-679Inhibition of human COLO-679 cell growth0.233615191Sanger
A172Inhibition of human A172 cell growth0.793833133Sanger
BHT-101Inhibition of human BHT-101 cell growth0.021828824Sanger
NCI-H2347Inhibition of human NCI-H2347 cell growth1.222880327Sanger
SW1710Inhibition of human SW1710 cell growth0.388261188Sanger
UACC-62Inhibition of human UACC-62 cell growth0.034354887Sanger
K5Inhibition of human K5 cell growth1.766107549Sanger
ES7Inhibition of human ES7 cell growth0.27033996Sanger
DOKInhibition of human DOK cell growth1.342150261Sanger
SW780Inhibition of human SW780 cell growth5.799582893Sanger
A388Inhibition of human A388 cell growth0.167275521Sanger
BT-474Inhibition of human BT-474 cell growth3.866961281Sanger
ES3Inhibition of human ES3 cell growth0.358533564Sanger
EPLC-272HInhibition of human EPLC-272H cell growth0.702975668Sanger
D-566MGInhibition of human D-566MG cell growth0.115749026Sanger
EFM-19Inhibition of human EFM-19 cell growth1.585998219Sanger
COLO-741Inhibition of human COLO-741 cell growth1.369230633Sanger
BXPC-3Inhibition of human BxPC-3 cell growth2.48062613Sanger
COLO-792Inhibition of human COLO-792 cell growth0.24749448Sanger
C2BBe1Inhibition of human C2BBe1 cell growth0.266244558Sanger
C32Inhibition of human C32 cell growth2.015948895Sanger
LB771-HNCInhibition of human LB771-HNC cell growth0.165941494Sanger
NYInhibition of human NY cell growth0.177619972Sanger
MDA-MB-361Inhibition of human MDA-MB-361 cell growth0.2263984Sanger
IA-LMInhibition of human IA-LM cell growth1.557806902Sanger
TE-9Inhibition of human TE-9 cell growth0.224850397Sanger
GB-1Inhibition of human GB-1 cell growth0.098687992Sanger
KNS-81-FDInhibition of human KNS-81-FD cell growth0.247513043Sanger
RMG-IInhibition of human RMG-I cell growth0.206617504Sanger
MPP-89Inhibition of human MPP-89 cell growth1.272168596Sanger
LB2518-MELInhibition of human LB2518-MEL cell growth0.177508639Sanger
YAPCInhibition of human YAPC cell growth0.801222174Sanger
HuO-3N1Inhibition of human HuO-3N1 cell growth2.031517397Sanger
TE-11Inhibition of human TE-11 cell growth0.150809776Sanger
SF-268Inhibition of human SF268 cell growth0.27160187Sanger
Hs-578-TInhibition of human Hs-578-T cell growth0.023589938Sanger
EW-22Inhibition of human EW-22 cell growth0.280097086Sanger
LAN-6Inhibition of human LAN-6 cell growth0.159920574Sanger
HCC1806Inhibition of human HCC1806 cell growth1.433478489Sanger
HuCCT1Inhibition of human HuCCT1 cell growth0.348027075Sanger
KINGS-1Inhibition of human KINGS-1 cell growth2.747224145Sanger
NCI-H1395Inhibition of human NCI-H1395 cell growth0.61190025Sanger
NCI-H2342Inhibition of human NCI-H2342 cell growth0.26656531Sanger
SNU-423Inhibition of human SNU-423 cell growth0.325009457Sanger
SNU-449Inhibition of human SNU-449 cell growth0.372394687Sanger
SW1990Inhibition of human SW1990 cell growth1.66757254Sanger
NCI-H28Inhibition of human NCI-H28 cell growth0.446634363Sanger
WM-115Inhibition of human WM-115 cell growth1.205324711Sanger
SNU-C2BInhibition of human SNU-C2B cell growth0.257360617Sanger
HuO9Inhibition of human HuO9 cell growth0.727395451Sanger
HUTU-80Inhibition of human HUTU-80 cell growth0.087005582Sanger
LXF-289 cell lineInhibition of human LXF-289 cell growth0.072846995Sanger
LoVoInhibition of human LoVo cell growth0.160931737Sanger
VMRC-RCZInhibition of human VMRC-RCZ cell growth7.75108629Sanger
U-118-MGInhibition of human U-118-MG cell growth0.190033482Sanger
KYSE-180Inhibition of human KYSE-180 cell growth0.184878394Sanger
SW 954Inhibition of human SW954 cell growth0.46695518Sanger
EW-1Inhibition of human EW-1 cell growth0.226802202Sanger
NCI-H2122Inhibition of human NCI-H2122 cell growth0.537562633Sanger
MKN1Inhibition of human MKN1 cell growth0.623270291Sanger
SK-N-ASInhibition of human SK-N-AS cell growth0.181183128Sanger
S-117Inhibition of human S-117 cell growth0.213291394Sanger
NCI-H2087Inhibition of human NCI-H2087 cell growth0.575072592Sanger
OVCAR-3Inhibition of human OVCAR-3 cell growth0.379172133Sanger
MG-63Inhibition of human MG-63 cell growth0.112478409Sanger
OVCAR-5Inhibition of human OVCAR-5 cell growth0.575715307Sanger
LS-411NInhibition of human LS-411N cell growth1.244201551Sanger
FTC-133Inhibition of human FTC-133 cell growth0.606634992Sanger
LCLC-97TM1Inhibition of human LCLC-97TM1 cell growth0.917272212Sanger
KLEInhibition of human KLE cell growth1.944366078Sanger
NCI-H1648Inhibition of human NCI-H1648 cell growth1.122238106Sanger
NCI-H1651Inhibition of human NCI-H1651 cell growth1.001072575Sanger
PANC-08-13Inhibition of human PANC-08-13 cell growth3.765648158Sanger
LU-99AInhibition of human LU-99A cell growth0.273763961Sanger
NCI-H1299Inhibition of human NCI-H1299 cell growth0.280244456Sanger
MZ7-melInhibition of human MZ7-mel cell growth1.732502682Sanger
GAMGInhibition of human GAMG cell growth0.212382794Sanger
SW1088Inhibition of human SW1088 cell growth0.454598803Sanger
SJRH30Inhibition of human SJRH30 cell growth0.136519612Sanger
TE-5Inhibition of human TE-5 cell growth0.884431689Sanger
no-11Inhibition of human no-11 cell growth2.836185456Sanger
RPMI-2650Inhibition of human RPMI-2650 cell growth0.238308792Sanger
TGBC1TKBInhibition of human TGBC1TKB cell growth1.127328867Sanger
LB996-RCCInhibition of human LB996-RCC cell growth0.250013841Sanger
SiHaInhibition of human SiHa cell growth0.26109316Sanger
IGR-1Inhibition of human IGR-1 cell growth0.300611664Sanger
SW1463Inhibition of human SW1463 cell growth64.83567552Sanger
MeWoInhibition of human Mewo cell growth0.484129425Sanger
UACC-893Inhibition of human UACC-893 cell growth1.434916989Sanger
UMUC3Inhibition of human UM-UC-3 cell growth0.163114805Sanger
MES-SAInhibition of human MES-SA cell growth1.109971123Sanger
EW-11Inhibition of human EW-11 cell growth0.434168748Sanger
DU-145Inhibition of human DU-145 cell growth0.052128211Sanger
EFO-21Inhibition of human EFO-21 cell growth2.602443991Sanger
CAL-51Inhibition of human CAL-51 cell growth0.349116361Sanger
ACNInhibition of human ACN cell growth0.696006695Sanger
CAMA-1Inhibition of human CAMA-1 cell growth0.660731318Sanger
BB49-HNCInhibition of human BB49-HNC cell growth2.014721556Sanger
A673Inhibition of human A673 cell growth0.053845201Sanger
A498Inhibition of human A498 cell growth1.494733605Sanger
ES1Inhibition of human ES1 cell growth0.12955536Sanger
CP50-MEL-BInhibition of human CP50-MEL-B cell growth0.069594691Sanger
COR-L105Inhibition of human COR-L105 cell growth0.710648035Sanger
D-542MGInhibition of human D-542MG cell growth0.462080112Sanger
D-423MGInhibition of human D-423MG cell growth0.472803694Sanger
CAS-1Inhibition of human CAS-1 cell growth2.779510964Sanger
SW626Inhibition of human SW626 cell growth0.422985238Sanger
NB12Inhibition of human NB12 cell growth0.136450823Sanger
NCI-H596Inhibition of human NCI-H596 cell growth3.322847181Sanger
EGI-1Inhibition of human EGI-1 cell growth1.246855772Sanger
PC3Inhibition of growth of human PC3 cell overexpressing Bcl20.2Scientific Literature
FaDuInhibition of human FADU cell growth0.525761811Sanger
NTERA-2-cl-D1Inhibition of human NTERA-S-cl-D1 cell growth0.166677579Sanger
HCE-TInhibition of human HCE-T cell growth0.230974723Sanger
MDA-MB-231Inhibition of human MDA-MB-231 cell growth0.108073579Sanger
HuP-T4Inhibition of human HuP-T4 cell growth0.542751341Sanger
GT3TKBInhibition of human GT3TKB cell growth0.300583408Sanger
RVH-421Inhibition of human RVH-421 cell growth0.252611132Sanger
HOP-92Inhibition of human HOP-92 cell growth0.357614389Sanger
SW872Inhibition of human SW872 cell growth0.058897714Sanger
SW900Inhibition of human SW900 cell growth2.769860617Sanger
DaoyInhibition of human Daoy cell growth0.140732268Sanger
DSH1Inhibition of human DSH1 cell growth0.516608471Sanger
ES4Inhibition of human ES4 cell growth0.516076639Sanger
SW1783Inhibition of human SW1783 cell growth0.213006201Sanger
TYK-nuInhibition of human TYK-nu cell growth0.324473633Sanger
NCI-H2029Inhibition of human NCI-H2029 cell growth14.37849949Sanger
NCI-H650Inhibition of human NCI-H650 cell growth0.645765399Sanger
OVCAR-8Inhibition of human OVCAR-8 cell growth0.470990667Sanger
NB69Inhibition of human NB69 cell growth0.876724917Sanger
HPAF-IIInhibition of human HPAF-II cell growth0.228111896Sanger
SK-OV-3Inhibition of human SK-OV-3 cell growth0.527129516Sanger
U-251Inhibition of human U251 cell growth0.38838118Sanger
RPMI-7951Inhibition of human RPMI-7951 cell growth0.888310442Sanger
SW620Inhibition of human SW620 cell growth0.960571365Sanger
GI-1Inhibition of human GI-1 cell growth0.127632403Sanger
SCC-25Inhibition of human SCC-25 cell growth0.522661109Sanger
SK-UT-1Inhibition of human SK-UT-1 cell growth0.028682302Sanger
UMC-11Inhibition of human UMC-11 cell growth1.313887106Sanger
VA-ES-BJInhibition of human VA-ES-BJ cell growth0.039563789Sanger
GCTInhibition of human GCT cell growth0.191134865Sanger
NCI-H358Inhibition of human NCI-H358 cell growth1.492621545Sanger
NUGC-3Inhibition of human NUGC-3 cell growth1.147931928Sanger
SW13Inhibition of human SW13 cell growth0.20359043Sanger
NCI-H1666Inhibition of human NCI-H1666 cell growth0.37831882Sanger
HEC-1Inhibition of human HEC-1 cell growth0.081370295Sanger
ACHNInhibition of human ACHN cell growth0.149001188Sanger
BB30-HNCInhibition of human BB30-HNC cell growth0.161744556Sanger
DMS-114Inhibition of human DMS-114 cell growth0.090707703Sanger
5637Inhibition of human 5637 cell growth0.551672889Sanger
DMS-53Inhibition of human DMS-53 cell growth1.321314402Sanger
D283 MedInhibition of human D-283MED cell growth0.284374002Sanger
D-336MGInhibition of human D-336MG cell growth0.957613526Sanger
Huh-7Inhibition of human HuH-7 cell growth0.032824011Sanger
YKG-1Inhibition of human YKG-1 cell growth0.029757621Sanger
COLO-824Inhibition of human COLO-824 cell growth0.691187601Sanger
NCI-H1838Inhibition of human NCI-H1838 cell growth2.156464338Sanger
MFM-223Inhibition of human MFM-223 cell growth0.846921728Sanger
NB14Inhibition of human NB14 cell growth0.076449797Sanger
BCPAPInhibition of human BCPAP cell growth0.24164393Sanger
NCI-H1703Inhibition of human NCI-H1703 cell growth0.217092011Sanger
SW1573Inhibition of human SW1573 cell growth0.240164302Sanger
MFE-280Inhibition of human MFE-280 cell growth4.587833921Sanger
IST-MEL1Inhibition of human IST-MEL1 cell growth0.227889139Sanger
NCI-H1792Inhibition of human NCI-H1792 cell growth0.690072234Sanger
MDA-MB-157Inhibition of human MDA-MB-157 cell growth0.841367277Sanger
MSTO-211HInhibition of human MSTO-211H cell growth0.788541691Sanger
PA-1Inhibition of human PA-1 cell growth0.133663878Sanger
MMAC-SFInhibition of human MMAC-SF cell growth3.143890356Sanger
HCC1419Inhibition of human HCC1419 cell growth0.918189025Sanger
NCI-H1355Inhibition of human NCI-H1355 cell growth1.29157577Sanger
HT-1376Inhibition of human HT-1376 cell growth1.902045717Sanger
HT-144Inhibition of human HT-144 cell growth0.152010452Sanger
KYSE-450Inhibition of human KYSE-450 cell growth0.175337779Sanger
HCC1187Inhibition of human HCC1187 cell growth0.424970723Sanger
NCI-H630Inhibition of human NCI-H630 cell growth0.807670581Sanger
NB10Inhibition of human NB10 cell growth0.214685309Sanger
NCI-H460Inhibition of human NCI-H460 cell growth0.305736702Sanger
OAW-28Inhibition of human OAW-28 cell growth0.293841727Sanger
KOSC-2Inhibition of human KOSC-2 cell growth0.495735381Sanger
KP-N-YNInhibition of human KP-N-YN cell growth15.93034849Sanger
Ca9-22Inhibition of human Ca9-22 cell growth0.00382021Sanger
769-PInhibition of human 769-P cell growth0.136837526Sanger
8305CInhibition of human 8305C cell growth3.910076738Sanger
D-247MGInhibition of human D-247MG cell growth0.935745258Sanger
CHP-212Inhibition of human CHP-212 cell growth4.572371509Sanger
COLO-678Inhibition of human COLO-678 cell growth3.306879515Sanger
J82Inhibition of human J82 cell growth1.128415008Sanger
SK-MG-1Inhibition of human SK-MG-1 cell growth2.582939264Sanger
ES6Inhibition of human ES6 cell growth0.373344385Sanger
CAL-27Inhibition of human CAL-27 cell growth0.135786294Sanger
ChaGo-K-1Inhibition of human ChaGo-K-1 cell growth0.295667727Sanger
A101DInhibition of human A101D cell growth0.087504155Sanger
SH-4Inhibition of human SH-4 cell growth0.226829873Sanger
MZ2-MELInhibition of human MZ2-MEL cell growth0.212442482Sanger
NCI-H1650Inhibition of human NCI-H1650 cell growth4.924919848Sanger
G-401Inhibition of human G-401 cell growth0.459929988Sanger
MC-IXCInhibition of human MC-IXC cell growth0.075330664Sanger
EW-16Inhibition of human EW-16 cell growth0.185278348Sanger
TCC-SUPInhibition of human TCCSUP cell growth0.36069556Sanger
SKG-IIIaInhibition of human SKG-IIIa cell growth0.576071209Sanger
HCC1954Inhibition of human HCC1954 cell growth0.893956645Sanger
SJSA-1Inhibition of human SJSA-1 cell growth0.326681692Sanger
SW1417Inhibition of human SW1417 cell growth1.908720267Sanger
NCI-H1755Inhibition of human NCI-H1755 cell growth1.621168199Sanger
HELInhibition of human HEL cell growth0.521663257Sanger
SW962Inhibition of human SW962 cell growth0.377909322Sanger
SW982Inhibition of human SW982 cell growth0.110697945Sanger
SCC-15Inhibition of human SCC-15 cell growth0.222852982Sanger
PC-3Inhibition of human PC-3 cell growth0.71542107Sanger
NCI-H2170Inhibition of human NCI-H2170 cell growth1.001693432Sanger
HCC1395Inhibition of human HCC1395 cell growth7.113127354Sanger
HCC1569Inhibition of human HCC1569 cell growth4.876881604Sanger
HT-1197Inhibition of human HT-1197 cell growth5.950879359Sanger
HSC-4Inhibition of human HSC-4 cell growth0.21323296Sanger
KALS-1Inhibition of human KALS-1 cell growth0.252548745Sanger
KYSE-70 cell lineInhibition of human KYSE-70 cell growth5.30761722Sanger
KGNInhibition of human KGN cell growth0.436233338Sanger
HCE-4Inhibition of human HCE-4 cell growth0.469060744Sanger
NCI-H1581Inhibition of human NCI-H1581 cell growth0.067635046Sanger
TE-1Inhibition of human TE-1 cell growth0.957478512Sanger
SF295Inhibition of human SF295 cell growth0.628932086Sanger
HCC38Inhibition of human HCC38 cell growth0.676390302Sanger
CAL-72Inhibition of human CAL-72 cell growth0.967539527Sanger
CAL-85-1Inhibition of human CAL-85-1 cell growth1.432697456Sanger
Calu-3Inhibition of human Calu-3 cell growth5.397398078Sanger
786-0Inhibition of human 786-0 cell growth6.974042205Sanger
BFTC-905Inhibition of human BFTC-905 cell growth0.70817857Sanger
BFTC-909Inhibition of human BFTC-909 cell growth0.25791299Sanger
CAKI-1Inhibition of human CAKI-1 cell growth0.216437815Sanger
COLO-800Inhibition of human COLO-800 cell growth0.183089715Sanger
EKVXInhibition of human EKVX cell growth7.141236924Sanger
Detroit 562Inhibition of human Detroit562 cell growth1.274468208Sanger
IST-MES1Inhibition of human IST-MES1 cell growth0.213733365Sanger
OMC-1Inhibition of human OMC-1 cell growth0.565464365Sanger
RT-112Inhibition of human RT-112 cell growth0.534544124Sanger
SK-MEL-28Inhibition of human SK-MEL-28 cell growth1.389836341Sanger
SW684Inhibition of human SW684 cell growth8.825788965Sanger
NCI-H2009Inhibition of human NCI-H2009 cell growth0.244659703Sanger
NCI-H727Inhibition of human NCI-H727 cell growth0.940971902Sanger
NB7Inhibition of human NB7 cell growth0.029278729Sanger
ES8Inhibition of human ES8 cell growth0.11926731Sanger
H-EMC-SSInhibition of human H-EMC-SS cell growth0.378225008Sanger
NCI-H1975Inhibition of human NCI-H1975 cell growth1.375864141Sanger
SASInhibition of human SAS cell growth0.033182953Sanger
No DataDisplacement of FAM-Bak from human Bcl-xL by FP assay6.58Scientific Literature
CaR-1Inhibition of human CaR-1 cell growth5.931072164Sanger
A204Inhibition of human A204 cell growth0.097844089Sanger
Calu-6Inhibition of human Calu-6 cell growth0.886751938Sanger
8-MG-BAInhibition of human 8-MG-BA cell growth0.15395776Sanger
AU565Inhibition of human AU565 cell growth0.352654308Sanger
SNU-387Inhibition of human SNU-387 cell growth0.247832541Sanger
PFSK-1Inhibition of human PFSK-1 cell growth0.17672808Sanger
PSN1Inhibition of human PSN1 cell growth0.167242236Sanger
NCI-H1563Inhibition of human NCI-H1563 cell growth0.124204857Sanger
TE-10Inhibition of human TE-10 cell growth1.234161757Sanger
Panc1005Inhibition of human PANC-10-05 cell growth1.102974918Sanger
RCC10RGBInhibition of human RCC10RGB cell growth13.83731599Sanger
LN-405Inhibition of human LN-405 cell growth1.583771456Sanger
SK-MEL-2Inhibition of human SK-MEL-2 cell growth0.230186138Sanger
NCI-H1623Inhibition of human NCI-H1623 cell growth0.59527964Sanger
EC-GI-10Inhibition of human EC-GI-10 cell growth0.469820769Sanger
DJM-1Inhibition of human DJM-1 cell growth0.519965404Sanger
DMS-273Inhibition of human DMS-273 cell growth0.100200109Sanger
CAL-39Inhibition of human CAL-39 cell growth0.341067798Sanger
C3AInhibition of human C3A cell growth1.820612531Sanger
A549Inhibition of human A549 cell growth0.014089929Sanger
C-33-AInhibition of human C-33-A cell growth0.109332236Sanger
M14Inhibition of human M14 cell growth2.827534131Sanger
NCI-H23Inhibition of human NCI-H23 cell growth0.34786041Sanger
SCHInhibition of human SCH cell growth0.367480141Sanger
EVSA-TInhibition of human EVSA-T cell growth0.139934055Sanger
HCC70Inhibition of human HCC70 cell growth0.857868032Sanger
KP-4Inhibition of human KP-4 cell growth0.454968542Sanger
OCUB-MInhibition of human OCUB-M cell growth0.242769462Sanger
LC-2-adInhibition of human LC-2-ad cell growth0.424154713Sanger
MEL-HOInhibition of human MEL-HO cell growth0.088161317Sanger
HGC-27Inhibition of human HGC-27 cell growth0.14048255Sanger
RERF-LC-MSInhibition of human RERF-LC-MS cell growth0.035186141Sanger
HCC2998Inhibition of human HCC2998 cell growth5.891437349Sanger
KNS-62Inhibition of human KNS-62 cell growth0.559451746Sanger
GAKInhibition of human GAK cell growth2.027884233Sanger
RH-18Inhibition of human RH-18 cell growth1.07462418Sanger
TE-8Inhibition of human TE-8 cell growth0.129261732Sanger
NCI-H441Inhibition of human NCI-H441 cell growth1.729198489Sanger
IGROV-1Inhibition of human IGROV-1 cell growth0.453621559Sanger
T-24Inhibition of human T-24 cell growth0.294556336Sanger
SCC-9Inhibition of human SCC-9 cell growth0.957159725Sanger
HT-29Inhibition of human HT-29 cell growth1.464374223Sanger
T98GInhibition of human T98G cell growth0.606121996Sanger
RXF393Inhibition of human RXF393 cell growth1.211592973Sanger
SW837Inhibition of human SW837 cell growth2.390259649Sanger
U-2-OSInhibition of human U-2-OS cell growth0.551816343Sanger
NCI-H747Inhibition of human NCI-H747 cell growth0.129633376Sanger
KYSE-410Inhibition of human KYSE-410 cell growth0.877179178Sanger
LS-513Inhibition of human LS-513 cell growth0.606504579Sanger
ESS-1Inhibition of human ESS-1 cell growth0.140874621Sanger
MKN28Inhibition of human MKN28 cell growth1.132093983Sanger
KS-1Inhibition of human KS-1 cell growth0.321781672Sanger
LB373-MEL-DInhibition of human LB373-MEL-D cell growth0.430920354Sanger
LB2241-RCCInhibition of human LB2241-RCC cell growth0.146583214Sanger
HOP-62Inhibition of human HOP-62 cell growth0.365388539Sanger
639-VInhibition of human 639-V cell growth0.521382157Sanger
A253Inhibition of human A253 cell growth0.570186374Sanger
D-392MGInhibition of human D-392MG cell growth1.419831212Sanger
OE19Inhibition of human OE19 cell growth5.977545308Sanger
A-375Inhibition of human A375 cell growth0.088830075Sanger
HMV-2 cell lineInhibition of human HMV-II cell growth0.309307299Sanger
SK-MEL-3Inhibition of human SK-MEL-3 cell growth0.692574822Sanger
MHH-ES-1Inhibition of human MHH-ES-1 cell growth0.50038724Sanger
KYSE-140Inhibition of human KYSE-140 cell growth0.186431761Sanger
NCI-H1993Inhibition of human NCI-H1993 cell growth1.040036699Sanger
OS-RC-2Inhibition of human OS-RC-2 cell growth0.737249433Sanger
DBTRG-05MGInhibition of human DBTRG-05MG cell growth1.457808091Sanger
BHYInhibition of human BHY cell growth0.701651807Sanger
OE33Inhibition of human OE33 cell growth0.695431335Sanger
TGBC24TKBInhibition of human TGBC24TKB cell growth0.226539717Sanger
JARInhibition of human JAR cell growth0.002601646Sanger
TK-10Inhibition of human TK10 cell growth0.462023742Sanger
GMS-10Inhibition of human GMS-10 cell growth0.44325857Sanger
NCI-H2030Inhibition of human NCI-H2030 cell growth2.805531489Sanger
KU-19-19Inhibition of human KU-19-19 cell growth0.440307911Sanger
HNInhibition of human HN cell growth0.231342496Sanger
NCI-H2052Inhibition of human NCI-H2052 cell growth1.392934956Sanger
SW756Inhibition of human SW756 cell growth0.112363177Sanger
G-361Inhibition of human G-361 cell growth0.124951077Sanger
NCI-H2452Inhibition of human NCI-H2452 cell growth0.754248794Sanger
SF539Inhibition of human SF539 cell growth0.470139885Sanger
HCT-116Inhibition of human HCT-116 cell growth0.052657848Sanger
ZR-75-30Inhibition of human ZR-75-30 cell growth1.422077741Sanger
no-10Inhibition of human no-10 cell growth0.276994397Sanger
RH-1Inhibition of human RH-1 cell growth0.157724254Sanger
MZ1-PCInhibition of human MZ1-PC cell growth0.634910649Sanger
SHP-77Inhibition of human SHP-77 cell growth0.451411021Sanger
SIMAInhibition of human SIMA cell growth0.664317554Sanger
KNS-42Inhibition of human KNS-42 cell growth2.544275669Sanger
DK-MGInhibition of human DK-MG cell growth2.902205601Sanger
Aspc-1Inhibition of human AsPC-1 cell growth0.973461503Sanger
CP66-MELInhibition of human CP66-MEL cell growth1.203294245Sanger
CAL-54Inhibition of human CAL-54 cell growth0.160738895Sanger
LOXIMVIInhibition of human LOXIMVI cell growth0.270707331Sanger
HOSInhibition of human HOS cell growth0.084705478Sanger
JEG-3Inhibition of human JEG-3 cell growth0.735697684Sanger
SK-MES-1Inhibition of human SK-MES-1 cell growth1.044939511Sanger
MIA PaCa-2Inhibition of human MIA-PaCa-2 cell growth0.479111467Sanger
SK-N-FIInhibition of human SK-N-FI cell growth0.327753984Sanger
U-87 MGInhibition of human U-87-MG cell growth0.082236585Sanger
HSC-3Inhibition of human HSC-3 cell growth0.286447788Sanger
NCI-H2228Inhibition of human NCI-H2228 cell growth0.661730438Sanger
LB1047-RCCInhibition of human LB1047-RCC cell growth0.319335821Sanger
NEC8Inhibition of human NEC8 cell growth0.145282377Sanger
HTC-C3Inhibition of human HTC-C3 cell growth1.584197548Sanger
NCI-H1437Inhibition of human NCI-H1437 cell growth0.538336742Sanger
NCI-H2405Inhibition of human NCI-H2405 cell growth0.674567186Sanger
RCM-1Inhibition of human RCM-1 cell growth3.389410458Sanger
MCF7Inhibition of human MCF7 cell growth0.336900717Sanger
8505CInhibition of human 8505C cell growth0.221287615Sanger
BPH-1Inhibition of human BPH-1 cell growth0.285812008Sanger
COLO-680NInhibition of human COLO-680N cell growth1.434750548Sanger
D-263MGInhibition of human D-263MG cell growth0.283492957Sanger
A-431Inhibition of human A431 cell growth1.469122083Sanger
BT-549Inhibition of human BT-549 cell growth0.679860261Sanger
A2058Inhibition of human A2058 cell growth0.366906952Sanger
D-502MGInhibition of human D-502MG cell growth4.922019924Sanger
ONS-76Inhibition of human ONS-76 cell growth0.325261762Sanger
ETK-1Inhibition of human ETK-1 cell growth0.788280727Sanger
SN12CInhibition of human SN12C cell growth1.106997062Sanger
T47DInhibition of human T47D cell growth0.690672858Sanger
HT-1080Inhibition of human HT-1080 cell growth0.255526029Sanger
OAW-42Inhibition of human OAW-42 cell growth0.491976169Sanger
OC-314Inhibition of human OC-314 cell growth0.210151202Sanger
EFO-27Inhibition of human EFO-27 cell growth0.117212588Sanger
647-VInhibition of human 647-V cell growth0.088427966Sanger
RO82-W-1Inhibition of human RO82-W-1 cell growth0.39777212Sanger
SK-LMS-1Inhibition of human SK-LMS-1 cell growth0.271512527Sanger
NCI-H522Inhibition of human NCI-H522 cell growth2.084568751Sanger
SK-HEP-1Inhibition of human SK-HEP-1 cell growth1.513696996Sanger
NCI-H520Inhibition of human NCI-H520 cell growth0.605663335Sanger
MEL-JUSOInhibition of human MEL-JUSO cell growth0.438583966Sanger
GCIYInhibition of human GCIY cell growth0.020826626Sanger
No DataBinding affinity to human Bcl2 by ELISA0.7Scientific Literature
No DataDisplacement of FAM-Bid from human Mcl1 by FP assay1.03Scientific Literature
IST-SL1Inhibition of human IST-SL1 cell growth0.438362976Sanger
NB6Inhibition of human NB6 cell growth2.485895607Sanger
GI-ME-NInhibition of human GI-ME-N cell growth0.403175632Sanger
NB13Inhibition of human NB13 cell growth0.158009203Sanger
NCI-H661Inhibition of human NCI-H661 cell growth0.201668302Sanger
LS-123Inhibition of human LS-123 cell growth2.195021848Sanger
NB17Inhibition of human NB17 cell growth1.064232625Sanger
KYSE-150 cell lineInhibition of human KYSE-150 cell growth0.465109694Sanger
RT4Inhibition of human RT4 cell growth10.61829015Sanger
SK-N-DZInhibition of human SK-N-DZ cell growth0.206814505Sanger
SW948Inhibition of human SW948 cell growth32.72407351Sanger
NCI-H1048Inhibition of human NCI-H1048 cell growth0.214268581Sanger
HSC-2Inhibition of human HSC-2 cell growth0.663804899Sanger
NCI-H810Inhibition of human NCI-H810 cell growth0.666041032Sanger
SF126Inhibition of human SF126 cell growth0.057072151Sanger
AN3-CAInhibition of human AN3-CA cell growth0.897582716Sanger
LNCaP-Clone-FGCInhibition of human LNCaP-Clone-FGC cell growth0.534717344Sanger
SK-MEL-24Inhibition of human SK-MEL-24 cell growth0.409914778Sanger
T84Inhibition of human T84 cell growth13.87372828Sanger
SCC-4Inhibition of human SCC-4 cell growth1.302361298Sanger
CAPAN-1Inhibition of human CAPAN-1 cell growth10.84385977Sanger
MKN7Inhibition of human MKN7 cell growth4.469010413Sanger
PANC-03-27Inhibition of human PANC-03-27 cell growth0.474135089Sanger
NCI-H2126Inhibition of human NCI-H2126 cell growth0.782367265Sanger
HO-1-N-1Inhibition of human HO-1-N-1 cell growth1.418559613Sanger
GOTOInhibition of human GOTO cell growth0.170946609Sanger
NCI-H1793Inhibition of human NCI-H1793 cell growth0.745254879Sanger
A2780Inhibition of human A2780 cell growth0.218457236Sanger
A-427Inhibition of human A427 cell growth0.044693196Sanger
KYSE-270Inhibition of human KYSE-270 cell growth1.075766037Sanger
UACC-257Inhibition of human UACC-257 cell growth0.551786546Sanger
HLEInhibition of human HLE cell growth0.120990772Sanger
KURAMOCHIInhibition of human KURAMOCHI cell growth1.935154174Sanger
SW48Inhibition of human SW48 cell growth0.237988958Sanger
LS-1034Inhibition of human LS-1034 cell growth1.36440304Sanger
SW1116Inhibition of human SW1116 cell growth8.447900931Sanger
H4Inhibition of human H4 cell growth0.408124094Sanger
MKN45Inhibition of human MKN45 cell growth0.337751453Sanger
TE-6Inhibition of human TE-6 cell growth24.50078113Sanger
G-402Inhibition of human G-402 cell growth0.192980139Sanger
LB831-BLCInhibition of human LB831-BLC cell growth0.744784771Sanger
HCT-15Inhibition of human HCT-15 cell growth0.20155681Sanger
DoTc2-4510Inhibition of human DoTc2-4510 cell growth1.475193253Sanger
CWR22RInhibition of human 22RV1 cell growth1.02806151Sanger
CAL-33Inhibition of human CAL-33 cell growth0.816624417Sanger
AGSInhibition of human AGS cell growth0.037531639Sanger
CAL-62Inhibition of human CAL-62 cell growth0.307520662Sanger
COR-L23Inhibition of human COR-L23 cell growth0.590666334Sanger
CW-2Inhibition of human CW-2 cell growth0.445867258Sanger
RKOInhibition of human RKO cell growth0.015174058Sanger
NMC-G1Inhibition of human NMC-G1 cell growth0.50459104Sanger
NCI-H292Inhibition of human NCI-H292 cell growth0.360234165Sanger
RDInhibition of human RD cell growth0.960313966Sanger
EW-7Inhibition of human EW-7 cell growth0.1668682Sanger
YH-13Inhibition of human YH-13 cell growth0.070594574Sanger
NCI-H1573Inhibition of human NCI-H1573 cell growth7.075371847Sanger
NOS-1Inhibition of human NOS-1 cell growth0.235162386Sanger
HD-MY-ZInhibition of human HD-MY-Z cell growth0.395228974Sanger
MDA-MB-453Inhibition of human MDA-MB-453 cell growth0.151883272Sanger
HuP-T3Inhibition of human HuP-T3 cell growth1.286118799Sanger
KM12Inhibition of human KM12 cell growth1.882498719Sanger
MDA-MB-175-VIIInhibition of human MDA-MB-175-VII cell growth0.451194847Sanger
NCI-H1693Inhibition of human NCI-H1693 cell growth1.254767128Sanger
LCLC-103H cell lineInhibition of human LCLC-103H cell growth0.210378708Sanger
NH-12Inhibition of human NH-12 cell growth0.172134006Sanger
HT55Inhibition of human HT55 cell growth0.65087218Sanger
HCC1937Inhibition of human HCC1937 cell growth1.638072097Sanger
HT-3Inhibition of human HT-3 cell growth0.192061048Sanger
NCI-H2291Inhibition of human NCI-H2291 cell growth20.98869585Sanger
M059JInhibition of human M059J cell growth1.304050253Sanger
SAOS-2Inhibition of human Saos-2 cell growth0.61268092Sanger
PC-14Inhibition of human PC-14 cell growth0.330629456Sanger
BENInhibition of human BEN cell growth7.40830005Sanger
CFPAC-1Inhibition of human CFPAC-1 cell growth0.522059872Sanger
Capan-2Inhibition of human Capan-2 cell growth6.037318763Sanger
CGTH-W-1Inhibition of human CGTH-W-1 cell growth0.18597798Sanger
CHL-1Inhibition of human CHL-1 cell growth0.011895109Sanger

Solubility

Solubility (25°C) * In vitro DMSO 115 mg/mL (200.45 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (6.97 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.43 mL 87.15 mL 174.31mL
0.5 mM 3.49 mL 17.43 mL 34.86 mL
1 mM 1.74 mL 8.72 mL 17.43 mL
5 mM 0.35 mL 1.74 mL 3.49 mL

*The above data is based on the productmolecular weight 573.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10255 ABT-737 <1 mg/mL 163 mg/mL <1 mg/mL
A10022 ABT-263 (Navitoclax) <1 mg/mL 195 mg/mL <1 mg/mL
A10665 Obatoclax mesylate (GX15-070) <1 mg/mL 83 mg/mL <1 mg/mL
A10955 TW-37 <1 mg/mL 115 mg/mL 4 mg/mL
A10984 VX-765 <1 mg/mL 102 mg/mL 102 mg/mL
A11090 PAC-1 <1 mg/mL 78 mg/mL 16 mg/mL
A10491 JNJ 26854165 <1 mg/mL 66 mg/mL 2 mg/mL
A11931 RITA (NSC 652287) <1 mg/mL 115 mg/mL 4 mg/mL
A10522 Lenalidomide (CC-5013) <1 mg/mL 52 mg/mL <1 mg/mL
A10743 Pomalidomide (CC-4047) <1 mg/mL 55 mg/mL <1 mg/mL
A11163 AT-406 <1 mg/mL 112 mg/mL 112 mg/mL
A11002 YM155 89 mg/mL 55 mg/mL 6 mg/mL
A10935 Tipifarnib (Zarnestra) <1 mg/mL 83 mg/mL <1 mg/mL
A10657 Nutlin-3 <1 mg/mL 116 mg/mL 116 mg/mL

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