TWS119

Catalog No.: A11223

GSK-3 Inhibitor

TWS119

TWS119 Chemical Structure

CAS NO. 601514-19-6

TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$75.00
25 mg
$160.00
50 mg
$250.00
10mM * 1mL in DMSO
$70.00
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Biological Activity

TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.
Targets
GSK-3β (Cell-free assay)
30 nM
In vitro (25°C) DMSO 58 mg/mL (182.19 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.42 mL 157.08 mL 314.17 mL
0.5 mM 6.28 mL 31.42 mL 62.83 mL
1 mM 3.14 mL 15.71 mL 31.42 mL
5 mM 0.63 mL 3.14 mL 6.28 mL

*The above data is based on the productmolecular weight 318.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11223
Actions Inhibitor
CAS No. 601514-19-6
Formula C18H14N4O2
M. Wt 318.3
Purity >98%
Synonyms TWS-119
SMILES C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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