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Biological Activity
TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.
Targets
| GSK-3β (Cell-free assay) | ||||
| 30 nM |
| In vitro (25°C) | DMSO | 58 mg/mL (182.19 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.42 mL | 157.08 mL | 314.17 mL |
| 0.5 mM | 6.28 mL | 31.42 mL | 62.83 mL |
| 1 mM | 3.14 mL | 15.71 mL | 31.42 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
*The above data is based on the productmolecular weight 318.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11223 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 601514-19-6 |
| Formula | C18H14N4O2 |
| M. Wt | 318.3 |
| Purity | >98% |
| Synonyms | TWS-119 |
| SMILES | C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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