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Vatalanib (PTK787) 2HCl

Catalog No.: A10967

VEGFR inhibitor

Vatalanib (PTK787) 2HCl

Vatalanib (PTK787) 2HCl Chemical Structure

CAS NO. 212141-51-0

Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2. CAS: 212141-51-0 (HCl) 212141-54-3 (Free base)

Availability: In stock

Package Price Qty
10 mg
$40.00
50 mg
$75.00
100 mg
$120.00
10mM * 1mL in DMSO
$55.00
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Biological Activity

Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2. CAS: 212141-51-0 (HCl) 212141-54-3 (Free base)
Targets
Target Value
VEGFR2/KDRIC50: 37nM
VEGFR1/FLT1IC50: 77nM
VEGFR2/Flk1IC50: 270nM
PDGFRβIC50: 580nM
VEGFR3/FLT4IC50: 660nM
c-KitIC50: 730nM
c-FmsIC50: 1.4μM
In vitro DMSO 77 mg/mL (183.45 mM)
Water 9 mg/mL (21.44 mM)
Ethanol 5 mg/mL (11.91 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.83 mL 119.13 mL 238.27 mL
0.5 mM 4.77 mL 23.83 mL 47.65 mL
1 mM 2.38 mL 11.91 mL 23.83 mL
5 mM 0.48 mL 2.38 mL 4.77 mL

*The above data is based on the productmolecular weight 419.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10967
Actions Inhibitor
CAS No. 212141-51-0
Formula C20H17Cl3N4
M. Wt 419.7
Purity >98%
Synonyms Vatalanib,PTK787,PTK/ZK
SMILES C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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