Vatalanib (PTK787) 2HCl

Catalog No.: A10967

VEGFR inhibitor

Vatalanib (PTK787) 2HCl

Vatalanib (PTK787) 2HCl Chemical Structure

CAS NO. 212141-51-0

Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2. CAS: 212141-51-0 (HCl) 212141-54-3 (Free base)

Availability: In stock

Package Price Qty
10 mg

Regular Price: $40.00

Special Price $32.00

25 mg

Regular Price: $80.00

Special Price $64.00

50 mg

Regular Price: $140.00

Special Price $112.00

100 mg

Regular Price: $250.00

Special Price $200.00

10mM * 1mL in DMSO
$76.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2. CAS: 212141-51-0 (HCl) 212141-54-3 (Free base)
Targets
Target Value
VEGFR2/KDRIC50: 37nM
VEGFR1/FLT1IC50: 77nM
VEGFR2/Flk1IC50: 270nM
PDGFRβIC50: 580nM
VEGFR3/FLT4IC50: 660nM
c-KitIC50: 730nM
c-FmsIC50: 1.4μM
In vitro DMSO 85 mg/mL (202.51 mM)
Water 10 mg/mL (23.82 mM)
Ethanol 6 mg/mL (14.29 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.83 mL 119.13 mL 238.27 mL
0.5 mM 4.77 mL 23.83 mL 47.65 mL
1 mM 2.38 mL 11.91 mL 23.83 mL
5 mM 0.48 mL 2.38 mL 4.77 mL

*The above data is based on the productmolecular weight 419.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10967
Actions Inhibitor
M. Wt 419.7
Formula C20H17Cl3N4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 212141-51-0
Synonyms Vatalanib,PTK787,PTK/ZK
SMILES C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl

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