Biological Activity
Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2. CAS: 212141-51-0 (HCl) 212141-54-3 (Free base)
Targets
Target | Value |
---|---|
VEGFR2/KDR | IC50: 37nM |
VEGFR1/FLT1 | IC50: 77nM |
VEGFR2/Flk1 | IC50: 270nM |
PDGFRβ | IC50: 580nM |
VEGFR3/FLT4 | IC50: 660nM |
c-Kit | IC50: 730nM |
c-Fms | IC50: 1.4μM |
In vitro | DMSO | 77 mg/mL (183.45 mM) | |
Water | 9 mg/mL (21.44 mM) | ||
Ethanol | 5 mg/mL (11.91 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.83 mL | 119.13 mL | 238.27 mL |
0.5 mM | 4.77 mL | 23.83 mL | 47.65 mL |
1 mM | 2.38 mL | 11.91 mL | 23.83 mL |
5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
*The above data is based on the productmolecular weight 419.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10967 |
---|---|
Actions | Inhibitor |
CAS No. | 212141-51-0 |
Formula | C20H17Cl3N4 |
M. Wt | 419.7 |
Purity | >98% |
Synonyms | Vatalanib,PTK787,PTK/ZK |
SMILES | C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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