Vinorelbine (Navelbine)

Catalog No.: A10976

Vinorelbine (Navelbine)

Vinorelbine (Navelbine) Chemical Structure

CAS NO. 71486-22-1

Vinorelbine is the first 5´NOR semi-synthetic vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus.

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10 mg
$60.00
25 mg
$110.00
50 mg
$180.00
100 mg
$300.00
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  • Rotem Ben-Hamo, .et al. Predicting and affecting response to cancer therapy based on pathway-level biomarkers, Nat Commun, 2020, 11: 3296
  • Roma Kaul, .et al. Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner, Br J Cancer, 2019, 121, pages611-621 PMID: 31481735
  • Nicholas F. Dybdal-Hargreaves, .et al. Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin, Oncotarget, 2018, Jan 19; 9(5): 5545-5561 PMID: 29464017
  • APRIL L. RISINGER, .et al. Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time, Anticancer Res, 2015, Nov; 35(11): 5845-5850. PMID: 26504006

Biological Activity

Vinorelbine is the first 5´NOR semi-synthetic vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus.
In vitro DMSO 99 mg/mL (91.73 mM)
Water Warmed: 99 mg/mL (91.73 mM)
Ethanol Warmed: 99 mg/mL (91.73 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.84 mL 64.19 mL 128.39 mL
0.5 mM 2.57 mL 12.84 mL 25.68 mL
1 mM 1.28 mL 6.42 mL 12.84 mL
5 mM 0.26 mL 1.28 mL 2.57 mL

*The above data is based on the productmolecular weight 778.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10976
CAS No. 71486-22-1
Formula C45H54N4O8
M. Wt 778.9
Solubility DMSO
Purity >98%
SMILES CCC1=C[[email protected]]2C[[email protected]@](C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[[email protected]]78CCN9[[email protected]]7[[email protected]@](C=CC9)([[email protected]]([[email protected]@]([[email protected]@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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